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Novel approach to antitumor antibiotics: Using the power of benzyne in synthesis

Stoltz, Brian M. (2012) Novel approach to antitumor antibiotics: Using the power of benzyne in synthesis. In: ACS National Meeting & Exposition, August 19-23, 2012, Philadelphia, PA. http://resolver.caltech.edu/CaltechAUTHORS:20120822-092222870

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Abstract

We have initiated a research program directed toward the tetrahydroisoquinoline (THIQ) antitumor antibiotics, a class of bioactive alkaloids with existing clin. applications. Central to our approach is the development of new aryne annulation methods for the synthesis of isoquinolines. Our initial application of this method in a THIQ synthesis was to a concise asym. total synthesis of (-)-quinocarcin. Our current work in the area will be discussed.


Item Type:Conference or Workshop Item (Paper)
Record Number:CaltechAUTHORS:20120822-092222870
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120822-092222870
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:33438
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Aug 2012 22:59
Last Modified:27 Aug 2012 22:59

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