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The Distribution of S^(35)-Labeled Bovine Serum Albumin in Newborn and Immunologically Tolerant Adult Rabbits

Garvey, Justine S. and Eitzman, Donald V. and Smith, Richard T. (1960) The Distribution of S^(35)-Labeled Bovine Serum Albumin in Newborn and Immunologically Tolerant Adult Rabbits. Journal of Experimental Medicine, 112 (3). pp. 533-550. ISSN 0022-1007. http://resolver.caltech.edu/CaltechAUTHORS:20120926-073219893

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Abstract

The fate of injected S^(35)-labeled sulfanilic acid-azoalbumin in the serum, various organs, and liver fractions was compared in the newborn and adult rabbit and in specifically unresponsive and normal adult rabbits. Exponential decay of the injected antigen without the usual immune phase of elimination was observed in newborn and unresponsive adult animals. Comparison of organ distribution of radioactivity in adults and animals injected at birth and 21 days of age showed persistence in the liver at least as long as 3 weeks in all groups (which was the time chosen for observation). The slight differences in spleen and thymus concentrations with age are of undetermined significance. Comparison of the organ distribution of antigen in unresponsive adult rabbits and in normal ones showed slight differences which were similar to those predicted from previous immunization of adults which gave low grade antibody response. There was a slight selective accumulation of antigen in the nuclear fraction of liver homogenates of unresponsive animals, but no other differences were observed.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1084/jem.112.3.533DOIUNSPECIFIED
http://jem.rupress.org/content/112/3/533.abstractPublisherUNSPECIFIED
Additional Information:© 1960 Rockefeller University Press. Received for publication May 9, 1960. Supported in part by Grants-in-Aid of the National Institutes of Health (A2927, A1718, E-1355) and the American Heart Association. United States Public Health Service Postdoctorate Fellow. Part of this work was done as Senior Investigator of the National Arthritis and Rheumatism Foundation. Contribution 2581. The authors thank Dr. Dan H. Campbell for valuable discussions during the course of these studies and the preparation of the manuscript and Miss Rebecca Kent and Mrs. Caroline McNeill for their technical aid.
Funders:
Funding AgencyGrant Number
NIHA2927
NIHA1718
NIHE-1355
Public Health Service Postdoctoral FellowshipUNSPECIFIED
National Arthritis and Rheumatism Foundation Senior InvestigatorUNSPECIFIED
American Heart AssociationUNSPECIFIED
Record Number:CaltechAUTHORS:20120926-073219893
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20120926-073219893
Official Citation:THE DISTRIBUTION OF S35-LABELED BOVINE SERUM ALBUMIN IN NEWBORN AND IMMUNOLOGICALLY TOLERANT ADULT RABBITS Justine S. Garvey, Donald V. Eitzman, and Richard T. Smith 112:533-550. doi:10.1084/jem.112.3.533
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:34380
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:26 Sep 2012 14:52
Last Modified:27 Dec 2012 02:43

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