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Epithelial to mesenchymal transition: New and old insights from the classical neural crest model

Strobl-Mazzulla, Pablo H. and Bronner, Marianne E. (2012) Epithelial to mesenchymal transition: New and old insights from the classical neural crest model. Seminars in Cancer Biology, 22 (5-6). pp. 411-416. ISSN 1044-579X. http://resolver.caltech.edu/CaltechAUTHORS:20121115-133132015

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Abstract

The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.semcancer.2012.04.008DOIUNSPECIFIED
http://www.sciencedirect.com/science/article/pii/S1044579X12000648PublisherUNSPECIFIED
Additional Information:© 2012 Elsevier Ltd. Some of the work reviewed here is based on studies supported by the National Institutes of Health under Award Nos. R03DE022521 to MEB and PS-M, HD037105 and The California Institute of Technology.
Funders:
Funding AgencyGrant Number
NIHR03DE022521
NIHHD037105
CaltechUNSPECIFIED
Subject Keywords:Neural crest; EMT; Development
Record Number:CaltechAUTHORS:20121115-133132015
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20121115-133132015
Official Citation:Pablo H. Strobl-Mazzulla, Marianne E. Bronner, Epithelial to mesenchymal transition: New and old insights from the classical neural crest model, Seminars in Cancer Biology, Volume 22, Issues 5–6, October 2012, Pages 411-416, ISSN 1044-579X, 10.1016/j.semcancer.2012.04.008.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35491
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:16 Nov 2012 00:19
Last Modified:16 Nov 2012 00:19

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