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A structural interpretation of the acidity of groups associated with the hemes of hemoglobin and hemoglobin derivatives

Coryell, Charles D. and Pauling, Linus (1940) A structural interpretation of the acidity of groups associated with the hemes of hemoglobin and hemoglobin derivatives. Journal of Biological Chemistry, 132 (2). pp. 769-779. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:CORjbc40

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Abstract

Since the discovery by Bohr and coworkers in 1904 of the effect of acidity on the oxygen equilibrium of hemoglobin, there have been a large number of investigations directed towards clarification of the physicochemical relationships of acid groups with the hemes in hemoglobin and its derivatives. It is the purpose of this paper to analyze modern quantitative data, including those for ferrihemoglobin (methemoglobin), in order to throw new light on the general problem, to establish the ionization constant of an acid group in ferrihemoglobin previously unrecognized, and to give a structural interpretation of shifts in the pK of groups caused by changing chemical environment.


Item Type:Article
Additional Information:Copyright © 1940 by the American Society for Biochemistry and Molecular Biology. Received for publication, October 25, 1939. We are indebted to Dr. J. F. Taylor of Harvard University for making the results of his experiments available to us before their publication in detail.
Record Number:CaltechAUTHORS:CORjbc40
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:CORjbc40
Alternative URL:http://www.jbc.org/cgi/content/abstract/132/2/769
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3571
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Jun 2006
Last Modified:26 Dec 2012 08:55

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