Hong, Jong Wook and Chen, Yan and Anderson, W. French and Quake, Stephen R. (2006) Molecular biology on a microfluidic chip. Journal of Physics: Condensed Matter, 18 (18). S691-S701. ISSN 0953-8984 http://resolver.caltech.edu/CaltechAUTHORS:HONjpcm06
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We have developed microfluidic chips for automating molecular biology processes such as gene ligation and gene transformation from nanolitre sample volumes with parallel architecture. Unlike conventional tube methods with cumbersome pipetting procedures, all processes, including metering of samples, ligation and transformation, were carried out in the microfluidic chips through pneumatic control of the nanofluid. The microfluidic devices presented here offer an illustration of some of the basic physics that arises when trying to miniaturize and automate biological techniques.
|Additional Information:||Copyright © Institute of Physics and IOP Publishing Limited 2006. Received 26 August 2005, in final form 24 November 2005. Published 19 April 2006. Print publication: Issue 18 (10 May 2006) SPECIAL ISSUE ON THE PHYSICS OF BIODEVICES This work was supported in part by the National Science Foundation (NSF), the National Institute of Health grant NIH R01 H6002644-01A1, and Department of Defense Advanced Research Projects Agency (DARPA).|
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|Deposited By:||Archive Administrator|
|Deposited On:||25 Jun 2006|
|Last Modified:||26 Dec 2012 08:55|
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