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Phycomyces

Bergman, K. and Burke, Patricia V. and Cerdá-Olmedo, E. and David, C. N. and Delbrück, M. and Foster, K. W. and Goodell, E. W. and Heisenberg, M. and Meissner, G. and Zalokar, M. and Dennison, D. S. and Shropshire, W., Jr. (1969) Phycomyces. Bacteriological Reviews, 33 (1). pp. 99-157. ISSN 0005-3678. http://resolver.caltech.edu/CaltechAUTHORS:BERbactrev69

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Abstract

This monographic review on a fungus is not addressed to mycologists. None of the authors has been trained or has otherwise acquired a general proficiency in mycology. They are motivated by a common interest in the performances of signal handling exhibited by the sense organs of all organisms and by the desire to attack these as yet totally obscure aspects of molecular biology by the study of a microorganism with certain desirable properties. The sporangiophore of the fungus Phycomyces is a gigantic, single-celled, erect, cylindrical, aerial hypha. It is sensitive to at least four distinct stimuli: light, gravity, stretch, and some unknown stimulus by which it avoids solid objects. These stimuli control a common output, the growth rate, producing either temporal changes in growth rate or tropic responses. We are interested in the output because it gives us information about the reception of the various signals. In the absence of external stimuli, the growth rate is controlled by internal signals keeping the network of biochemical processes in balance. The external stimuli interact with the internal signals. We wish to inquire into the early steps of this interaction. For light, for instance, the cell must have a receptor pigment as the first mediator. What kind of a molecule is this pigment? Which organelle contains it? What chemical reaction happens after a light quantum has been absorbed? And how is the information introduced by this primary photochemical event amplified in a controlled manner and processed in the next step? How do a few quanta or a few molecules trigger macroscopic responses? Will we find ourselves confronted with devices wholly distinct from anything now known in biology?


Item Type:Article
Additional Information:Copyright 1969 American Society for Microbiology. We are very much indebted to E. S. Castle, A.Frey-Wyssling, H. Gruen, S. K. Malhotra, J.Matricon, M. Plempel, and R. M. Thornton for critical comments on various sections of this review, and to Patricia Reau for harmonizing substance and form.
Record Number:CaltechAUTHORS:BERbactrev69
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BERbactrev69
Alternative URL:http://mmbr.asm.org/cgi/content/abstract/33/1/99
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3723
Collection:CaltechAUTHORS
Deposited By: Lindsay Cleary
Deposited On:12 Jul 2006
Last Modified:26 Dec 2012 08:55

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