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A Review of Cavitation Uses and Problems in Medicine; Invited Lecture

Brennen, Christopher E. (2006) A Review of Cavitation Uses and Problems in Medicine; Invited Lecture. In: Cavitation: Turbo-machinery & Medical Applications, WIMRC FORUM 2006, 3 July 2006, Warwick Innovative Manufacturing Research Centre (WIMRC), Warwick University, UK. (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:BREwimrc06

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Abstract

There are an increasing number of biological and bioengineering contexts in which cavitation is either utilized to create some desired effect or occurs as a byproduct of some other process. In this review an attempt will be made to describe a cross-section of these cavitation phenomena. In the byproduct category we describe some of the cavitation generated by head injuries and in artifical heart valves. In the utilization category we review the cavitation produced during lithotripsy and phacoemulsification. As an additional example we describe the nucleation suppression phenomena encountered in supersaturated oxygen solution injection. Virtually all of these cavitation and nucleation phenomena are critically dependent on the existence of nucleation sites. In most conventional engineering contexts, the prediction and control of nucleation sites is very uncertain even when dealing with a simple liquid like water. In complex biological fluids, there is a much greater dearth of information. Moreover, all these biological contexts seem to involve transient, unsteady cavitation. Consequently they involve the difficult issue of the statistical coincidence of nucleation sites and transient low pressures. The unsteady, transient nature of the phenomena means that one must be aware of the role of system dynamics in vivo and in vitro. For example, the artificial heart valve problem clearly demonstrates the importance of structural flexibility in determining cavitation occurrence and cavitation damage. Other system issues are very important in the design of in vitro systems for the study of cavitation consequences. Another common feature of these phenomena is that often the cavitation occurs in the form of a cloud of bubbles and thus involves bubble interactions and bubble cloud phenomena. In this review we summarize these issues and some of the other characteristics of biological cavitation phenomena.


Item Type:Conference or Workshop Item (Lecture)
Additional Information:Many individuals provided me with valuable assistance in the preparation of this review, including Tim Colonius, Allan Acosta, Yoichiro Matsumoto, Aziz Anis, Michel Tanguay, Brant Maines, Morteza Gharib, Larry Crum, Tim Baldwin, James Antaki, and Eric Johnsen. Invited Lecture -- Cavitation: Turbo-machinery & Medical Applications; Warwick University, UK, 3rd July 2006; WIMRC FORUM 2006
Record Number:CaltechAUTHORS:BREwimrc06
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BREwimrc06
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3873
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:17 Jul 2006
Last Modified:26 Dec 2012 08:56

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