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Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide

Casey, James and Davidson, Norman (1977) Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide. Nucleic Acids Research, 4 (5). pp. 1539-1552. ISSN 0305-1048. http://resolver.caltech.edu/CaltechAUTHORS:CASnar77

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Abstract

The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte solutions containing high concentrations of formamide. Association rates to form DNA:DNA duplexes and DNA:RNA hybrids have been measured in these solvents. There is a temperature range in which DNA:DNA rates are negligible and RNA:DNA rates close to optimal.


Item Type:Article
Additional Information:Copyright © 1977 Oxford University Press. Received December 24, 1976. We are grateful to Drs. Doug Engel and Peter Chandler for their sustained interest and advice and to Dr. Chandler for permission to quote his studies on the stability of RNA in various solvents. This research has been supported by contract NO 1 CP 43306 with the Virus Cancer Program of the National Cancer Institute. J.C. has been supported by 1F22 CA03416 from the National Cancer Institute.
Record Number:CaltechAUTHORS:CASnar77
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:CASnar77
Alternative URL:http://nar.oxfordjournals.org/cgi/content/abstract/4/5/1539
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4017
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Jul 2006
Last Modified:26 Dec 2012 08:57

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