CaltechAUTHORS
  A Caltech Library Service

Using extracellular action potential recordings to constrain compartmental models

Gold, Carl and Henze, Darrell A. and Koch, Christof (2007) Using extracellular action potential recordings to constrain compartmental models. Journal of Computational Neuroscience, 23 (1). pp. 39-58. ISSN 0929-5313 . http://resolver.caltech.edu/CaltechAUTHORS:20130816-103135930

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20130816-103135930

Abstract

We investigate the use of extracellular action potential (EAP) recordings for biophysically faithful compartmental models. We ask whether constraining a model to fit the EAP is superior to matching the intracellular action potential (IAP). In agreement with previous studies, we find that the IAP method under-constrains the parameters. As a result, significantly different sets of parameters can have virtually identical IAP’s. In contrast, the EAP method results in a much tighter constraint. We find that the distinguishing characteristics of the waveform—but not its amplitude- resulting from the distribution of active conductances are fairly invariant to changes of electrode position and detailed cellular morphology. Based on these results, we conclude that EAP recordings are an excellent source of data for the purpose of constraining compartmental models.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s10827-006-0018-2DOIArticle
http://link.springer.com/article/10.1007%2Fs10827-006-0018-2PublisherArticle
Additional Information:Received: 8 June 2006 / Revised: 30 November 2006 / Accepted: 26 December 2006 / Published online: 2 February 2007 c 2007 Springer. We would like to thank Gy¨orgy Buzs´aki for allowing the use and publication of the CA1 pyramidal cell morphology D151 (Henze et al., 2000) and for many helpful discussions. This work was supported by National Institute of Mental Health (NIMH) Fellowship 1-F31-MH-070144-01A1 and Grant MH-12403, National Institute of Neurological Disorders and Stroke Grants NS-34994 and NS-43157, the NIMH-supported Conte Center for the Detection and Recognition of Objects, and the National Science Foundation.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
National Institute of Mental Health (NIMH) 1-F31-MH-070144-01A1
National Institute of Mental Health (NIMH) MH-12403
National Institute of Neurological Disorders and Stroke NS-34994
National Institute of Neurological Disorders and Stroke NS-43157
Conte Center for the Detection and Recognition of ObjectsUNSPECIFIED
NSFUNSPECIFIED
Subject Keywords:Compartmental model · Extracellular recording · Model constraint ·CA1 · Pyramidal neuron · Neuron simulation
Record Number:CaltechAUTHORS:20130816-103135930
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103135930
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40348
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:12 Jan 2008 02:21
Last Modified:03 Apr 2014 20:39

Repository Staff Only: item control page