CaltechAUTHORS
  A Caltech Library Service

Neural correlates of attention and working memory deficits in HIV patients

Chang, Linda and Speck, Oliver and Miller, Eric N. and Braun, Jochen and Jovicich, Jorge and Koch, Christof and Itti, Laurent and Ernst, Thomas (2001) Neural correlates of attention and working memory deficits in HIV patients. Neurology, 57 (6). pp. 1001-1007. ISSN 0028-3878. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103136216

[img]
Preview
PDF - Published Version
See Usage Policy.

1685Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20130816-103136216

Abstract

Objectives: To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1. Method: fMRI was used to evaluate brain activity in 11 patients with HIV and 11 age-, sex-, education-, and handedness-matched seronegative subjects, while performing a battery of tasks that required different levels of attention for working memory. Results: Patients with HIV showed greater brain activation (blood oxygenation level dependent signal changes) in some regions compared with control subjects while performing the same tasks. For the simpler tasks, patients with HIV showed greater activation in the parietal regions. However, with more difficult tasks, patients with HIV showed greater activation additionally in the frontal lobes. Reaction times during these tasks were slower but accuracy was similar in the patients with HIV compared with control subjects. Conclusion: Injury to the neural substrate caused by HIV infection may necessitate greater attentional modulation of the neural circuits, hence a greater use of the brain reserve; additional activation of the frontal lobes is required to perform the more complex tasks. The task-dependent increased frontal activation in patients with HIV suggests that the neural correlate of attentional deficits may be excessive attentional modulation as a result of frontostriatal brain injury.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1212/WNL.57.6.1001DOIArticle
http://www.neurology.org/content/57/6/1001.shortPublisherArticle
Additional Information:Copyright © 2001 by AAN Enterprises, Inc. Received July 3, 2000. Accepted April 22, 2001. The authors thank Dr. Paul Satz for the discussion of brain reserve and Dr. Geraint Rees for his advice regarding SPM. They also thank the Harbor-UCLA Imaging Center/InSight, Inc., Torrance, CA, for their support.
Group:Koch Laboratory, KLAB
Record Number:CaltechAUTHORS:20130816-103136216
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103136216
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40349
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:05 Feb 2008 23:37
Last Modified:02 Dec 2013 21:50

Repository Staff Only: item control page