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Spike propagation in dendrites with stochastic ion channels

Diba, Kamran and Koch, Christof and Segev, Idan (2006) Spike propagation in dendrites with stochastic ion channels. Journal of Computational Neuroscience, 20 (1). pp. 77-84. ISSN 0929-5313 . http://resolver.caltech.edu/CaltechAUTHORS:20130816-103139148

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Abstract

We investigate the effects of the stochastic nature of ion channels on the faithfulness, precision and reproducibility of electrical signal transmission in weakly active, dendritic membrane under in vitro conditions. The properties of forward and backpropagating action potentials (BPAPs) in the dendritic tree of pyramidal cells are the subject of intense empirical work and theoretical speculation (Larkum et al., 1999; Zhu, 2000; Larkum et al., 2001; Larkum and Zhu, 2002; Schaefer et al., 2003; Williams, 2004; Waters et al., 2005). We numerically simulate the effects of stochastic ion channels on the forward and backward propagation of dendritic spikes in Monte-Carlo simulations on a reconstructed layer 5 pyramidal neuron. We report that in most instances there is little variation in timing or amplitude for a single BPAP, while variable backpropagation can occur for trains of action potentials. Additionally, we find that the generation and forward propagation of dendritic Ca<sup>2+</sup> spikes are susceptible to channel variability. This indicates limitations on computations that depend on the precise timing of Ca<sup>2+</sup> spikes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s10870-006-4770-0DOIArticle
http://link.springer.com/article/10.1007%2Fs10870-006-4770-0PublisherArticle
Additional Information:Received: 3 June 2005 / Revised: 29 July 2005 / Accepted: 1 September 2005 / Published online: 20 February 2006 �C Springer Science + Business Media, Inc. 2006. The research described here was supported by the NIMH, the HFSP, the NSF, and a Sloan-Swartz Postdoctoral Fellowship to K.D. We thank Mickey London, Peter Steinmetz, and Andraes Schaefer for sharing their NEURON code, and Gy¨orgy Buzs´aki and David Robbe for comments.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
NIMHUNSPECIFIED
HFSPUNSPECIFIED
NSFUNSPECIFIED
Sloan-Swartz Postdoctoral FellowshipUNSPECIFIED
Subject Keywords:temporal precision; spike reliability; coincidence detection
Record Number:CaltechAUTHORS:20130816-103139148
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103139148
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40360
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:12 Jan 2008 01:51
Last Modified:03 Apr 2014 20:39

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