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Multiplication and stimulus invariance in a looming-sensitive neuron

Gabbiani, Fabrizio and Krapp, Holger G. and Hatsopoulos, Nicholas G. and Mo, Chunhui and Koch, Christof and Laurent, Gilles (2004) Multiplication and stimulus invariance in a looming-sensitive neuron. Journal of Physiology - Paris, 98 (1-3). pp. 19-34. ISSN 0928-4257. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103143472

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Abstract

Multiplicative operations and invariance of neuronal responses are thought to play important roles in the processing of neural information in many sensory systems. Yet the biophysical mechanisms that underlie both multiplication and invariance of neuronal responses in vivo, either at the single cell or at the network level, remain to a large extent unknown. Recent work on an identified neuron in the locust visual system (the LGMD neuron) that responds well to objects looming on a collision course towards the animal suggests that this cell represents a good model to investigate the biophysical basis of multiplication and invariance at the single neuron level. Experimental and theoretical results are consistent with multiplication being implemented by subtraction of two logarithmic terms followed by exponentiation via active membrane conductances, according to a×1/b=exp(log(a)−log(b)). Invariance appears to be in part due to non-linear integration of synaptic inputs within the dendritic tree of this neuron.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jphysparis.2004.03.001DOIArticle
http://www.sciencedirect.com/science/article/pii/S0928425704000683PublisherArticle
ORCID:
AuthorORCID
Laurent, Gilles0000-0002-2296-114X
Additional Information:Copyright © 2004 Elsevier Ltd. This work was supported by the Sloan Foundation, the National Institute of Mental Health (F.G., C.K.), the National Institute for Deafness and Communication Disorders (G.L.), the McKnight Foundation (G.L.) and the Center for Neuromorphic Engineering as part of the NSF Engineering Research Center programme. H.G.K. was supported by a travel grant of the Deutsche Forschungsgemeinschaft. F.G. is an Alfred P. Sloan research fellow.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
Alfred P. Sloan FoundationUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
National Institute on Deafness and Communication DisordersUNSPECIFIED
McKnight FoundationUNSPECIFIED
Center for Neuromorphic Engineering at CaltechUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
Subject Keywords:Looming; LGMD; DCMD; Multiplication; Invariance; Single neuron computation
Record Number:CaltechAUTHORS:20130816-103143472
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103143472
Official Citation:Fabrizio Gabbiani, Holger G. Krapp, Nicholas Hatsopoulos, Chun-Hui Mo, Christof Koch, Gilles Laurent, Multiplication and stimulus invariance in a looming-sensitive neuron, Journal of Physiology-Paris, Volume 98, Issues 1–3, January–June 2004, Pages 19-34, ISSN 0928-4257, http://dx.doi.org/10.1016/j.jphysparis.2004.03.001. (http://www.sciencedirect.com/science/article/pii/S0928425704000683)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40378
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:12 Jan 2008 00:20
Last Modified:20 Nov 2015 01:04

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