Gabbiani, Fabrizio and Krapp, Holger G. and Hatsopoulos, Nicholas G. and Mo, Chunhui and Koch, Christof and Laurent, Gilles (2004) Multiplication and stimulus invariance in a looming-sensitive neuron. Journal of Physiology - Paris, 98 (1-3). pp. 19-34. ISSN 0928-4257. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103143472
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Multiplicative operations and invariance of neuronal responses are thought to play important roles in the processing of neural information in many sensory systems. Yet the biophysical mechanisms that underlie both multiplication and invariance of neuronal responses in vivo, either at the single cell or at the network level, remain to a large extent unknown. Recent work on an identified neuron in the locust visual system (the LGMD neuron) that responds well to objects looming on a collision course towards the animal suggests that this cell represents a good model to investigate the biophysical basis of multiplication and invariance at the single neuron level. Experimental and theoretical results are consistent with multiplication being implemented by subtraction of two logarithmic terms followed by exponentiation via active membrane conductances, according to a×1/b=exp(log(a)−log(b)). Invariance appears to be in part due to non-linear integration of synaptic inputs within the dendritic tree of this neuron.
|Additional Information:||Copyright © 2004 Elsevier Ltd. This work was supported by the Sloan Foundation, the National Institute of Mental Health (F.G., C.K.), the National Institute for Deafness and Communication Disorders (G.L.), the McKnight Foundation (G.L.) and the Center for Neuromorphic Engineering as part of the NSF Engineering Research Center programme. H.G.K. was supported by a travel grant of the Deutsche Forschungsgemeinschaft. F.G. is an Alfred P. Sloan research fellow.|
|Group:||Koch Laboratory, KLAB|
|Subject Keywords:||Looming; LGMD; DCMD; Multiplication; Invariance; Single neuron computation|
|Official Citation:||Fabrizio Gabbiani, Holger G. Krapp, Nicholas Hatsopoulos, Chun-Hui Mo, Christof Koch, Gilles Laurent, Multiplication and stimulus invariance in a looming-sensitive neuron, Journal of Physiology-Paris, Volume 98, Issues 1–3, January–June 2004, Pages 19-34, ISSN 0928-4257, http://dx.doi.org/10.1016/j.jphysparis.2004.03.001. (http://www.sciencedirect.com/science/article/pii/S0928425704000683)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||KLAB Import|
|Deposited On:||12 Jan 2008 00:20|
|Last Modified:||20 Nov 2015 01:04|
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