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On the Origin of the Extracellular Action Potential Waveform: A Modeling Study

Gold, Carl and Henze, Darrell A. and Koch, Christof and Buzsáki, György (2006) On the Origin of the Extracellular Action Potential Waveform: A Modeling Study. Journal of Neurophysiology, 95 (5). pp. 3113-3128. ISSN 0022-3077. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103143835

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Abstract

Although extracellular unit recording is typically used for the detection of spike occurrences, it also has the theoretical ability to report about what are typically considered intracellular features of the action potential. We address this theoretical ability by developing a model system that captures features of experimentally recorded simultaneous intracellular and extracellular recordings of CA1 pyramidal neurons. We use the line source approximation method of Holt and Koch to model the extracellular action potential (EAP) voltage resulting from the spiking activity of individual neurons. We compare the simultaneous intracellular and extracellular recordings of CA1 pyramidal neurons recorded in vivo with model predictions for the same cells reconstructed and simulated with compartmental models. The model accurately reproduces both the waveform and the amplitude of the EAPs, although it was difficult to achieve simultaneous good matches on both the intracellular and extracellular waveforms. This suggests that accounting for the EAP waveform provides a considerable constraint on the overall model. The developed model explains how and why the waveform varies with electrode position relative to the recorded cell. Interestingly, each cell's dendritic morphology had very little impact on the EAP waveform. The model also demonstrates that the varied composition of ionic currents in different cells is reflected in the features of the EAP.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.00979.2005 DOIArticle
http://jn.physiology.org/content/95/5/3113.abstractPublisherArticle
Additional Information:Copyright © 2006 by the American Physiological Society. Submitted 19 September 2005. Accepted 24 January 2006. Published online before print February 8, 2006. This work was supported by National Institute of Mental Health (NIMH) Fellowship 1-F31-MH-070144-01A1 and Grant MH-12403, National Institute of Neurological Disorders and Stroke Grants NS-34994 and NS-43157, the NIMH-supported Conte Center for the Detection and Recognition of Objects, and the National Science Foundation.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
National Institute of Mental Health (NIMH)1-F31-MH-070144-01A1
National Institute of Mental Health (NIMH) MH-12403
National Institute of Neurological Disorders and Stroke NS-34994
National Institute of Neurological Disorders and Stroke NS-43157
Conte Center for the Detection and Recognition of ObjectsUNSPECIFIED
NSFUNSPECIFIED
Record Number:CaltechAUTHORS:20130816-103143835
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103143835
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40380
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:12 Jan 2008 01:55
Last Modified:19 Nov 2015 00:35

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