Prank, Klaus and Gabbiani, Fabrizio and Brabant, Georg (2000) Coding efficiency and information rates in transmembrane signaling. Biosystems, 55 (1-3). pp. 15-22. ISSN 0303-2647. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103221325
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20130816-103221325
A variety of cell types responds to hormonal stimuli by repetitive spikes in the intracellular concentration of calcium ([Ca<sup>2+</sup>]i) which have been demonstrated to encode information in their frequency, amplitude, and duration. These [Ca<sup>2+</sup>]i-spike trains are able to specifically regulate distinct cellular functions. Using a mathematical model for receptor-controlled [Ca<sup>2+</sup>]i oscillations in hepatocytes we investigate the encoding of fluctuating hormonal signals in [Ca<sup>2+</sup>]i-spike trains. The transmembrane information transfer is quantified by using an information-theoretic reverse-engineering approach which allows to reconstruct the dynamic hormonal stimulus from the [Ca<sup>2+</sup>]i-spike trains. This approach allows to estimate the accuracy of coding as well as the rate of transmembrane information transfer. We found that up to 87% of the dynamic stimulus information can be encoded in the [Ca<sup>2+</sup>]i-spike train at a maximum information transfer rate of 1.1 bit per [Ca<sup>2+</sup>]i-spike. These numerical results for humoral information transfer are in the same order as in a number of sensory neuronal systems despite several orders of magnitude different time scales of operation suggesting a universal principle of information processing in both biological systems.
|Additional Information:||© 2000 Elsevier Science. This work was supported by DFG under grants Pr 333:12–1 and Br 915:4–4.|
|Group:||Koch Laboratory, KLAB|
|Subject Keywords:||Intracellular calcium oscillations; Hepatocyte; Stimulus reconstruction; Information rate; Frequency coding; Temporal coding|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||KLAB Import|
|Deposited On:||11 Mar 2010 06:00|
|Last Modified:||11 Oct 2013 17:59|
Repository Staff Only: item control page