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Coding efficiency and information rates in transmembrane signaling

Prank, Klaus and Gabbiani, Fabrizio and Brabant, Georg (2000) Coding efficiency and information rates in transmembrane signaling. Biosystems, 55 (1-3). pp. 15-22. ISSN 0303-2647. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103221325

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Abstract

A variety of cell types responds to hormonal stimuli by repetitive spikes in the intracellular concentration of calcium ([Ca<sup>2+</sup>]i) which have been demonstrated to encode information in their frequency, amplitude, and duration. These [Ca<sup>2+</sup>]i-spike trains are able to specifically regulate distinct cellular functions. Using a mathematical model for receptor-controlled [Ca<sup>2+</sup>]i oscillations in hepatocytes we investigate the encoding of fluctuating hormonal signals in [Ca<sup>2+</sup>]i-spike trains. The transmembrane information transfer is quantified by using an information-theoretic reverse-engineering approach which allows to reconstruct the dynamic hormonal stimulus from the [Ca<sup>2+</sup>]i-spike trains. This approach allows to estimate the accuracy of coding as well as the rate of transmembrane information transfer. We found that up to 87% of the dynamic stimulus information can be encoded in the [Ca<sup>2+</sup>]i-spike train at a maximum information transfer rate of 1.1 bit per [Ca<sup>2+</sup>]i-spike. These numerical results for humoral information transfer are in the same order as in a number of sensory neuronal systems despite several orders of magnitude different time scales of operation suggesting a universal principle of information processing in both biological systems.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0303-2647(99)00078-7DOIArticle
http://www.sciencedirect.com/science/article/pii/S0303264799000787PublisherArticle
Additional Information:© 2000 Elsevier Science. This work was supported by DFG under grants Pr 333:12–1 and Br 915:4–4.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)Pr 333:12–1
Deutsche Forschungsgemeinschaft (DFG)Br 915:4–4
Subject Keywords:Intracellular calcium oscillations; Hepatocyte; Stimulus reconstruction; Information rate; Frequency coding; Temporal coding
Record Number:CaltechAUTHORS:20130816-103221325
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103221325
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40494
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:11 Mar 2010 06:00
Last Modified:11 Oct 2013 17:59

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