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Subthreshold Voltage Noise Due to Channel Fluctuations in Active Neuronal Membranes

Steinmetz, Peter N. and Manwani, Amit and Koch, Christof and London, Michael and Segev, Idan (2000) Subthreshold Voltage Noise Due to Channel Fluctuations in Active Neuronal Membranes. Journal of Computational Neuroscience, 9 (2). pp. 133-148. ISSN 0929-5313 . http://resolver.caltech.edu/CaltechAUTHORS:20130816-103229674

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Abstract

Voltage-gated ion channels in neuronal membranes fluctuate randomly between different conformational states due to thermal agitation. Fluctuations between conducting and nonconducting states give rise to noisy membrane currents and subthreshold voltage fluctuations and may contribute to variability in spike timing. Here we study subthreshold voltage fluctuations due to active voltage-gated Na+ and K+ channels as predicted by two commonly used kinetic schemes: the Mainen et al. (1995) (MJHS) kinetic scheme, which has been used to model dendritic channels in cortical neurons, and the classical Hodgkin-Huxley (1952) (HH) kinetic scheme for the squid giant axon. We compute the magnitudes, amplitude distributions, and power spectral densities of the voltage noise in isopotential membrane patches predicted by these kinetic schemes. For both schemes, noise magnitudes increase rapidly with depolarization from rest. Noise is larger for smaller patch areas but is smaller for increased model temperatures. We contrast the results from Monte Carlo simulations of the stochastic nonlinear kinetic schemes with analytical, closed-form expressions derived using passive and quasi-active linear approximations to the kinetic schemes. For all subthreshold voltage ranges, the quasi-active linearized approximation is accurate within 8% and may thus be used in large-scale simulations of realistic neuronal geometries.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1023/A:1008967807741DOIArticle
http://link.springer.com/article/10.1023/A%3A1008967807741PublisherArticle
Additional Information:Received June 28, 1999; Revised November 9, 1999; Accepted November 19, 1999. c2000 Kluwer Academic Publishers. This work was funded by NSF, NIMH, and the Sloan Center for Theoretical Neuroscience to C.K. and by the Israeli Academy of Science and the ONR to I.S.We would like to thank our collaborators Elad Schneidman and Yosef Yarom for their invaluable suggestions.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
NIMHUNSPECIFIED
Sloan Center for Theoretical NeuroscienceUNSPECIFIED
Israeli Academy of ScienceUNSPECIFIED
U.S. Office of Naval Research UNSPECIFIED
Subject Keywords:membrane noise, active ion channels, Markov kinetic models, stochastic ion channels
Record Number:CaltechAUTHORS:20130816-103229674
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103229674
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40520
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:11 Jan 2008 20:00
Last Modified:03 Apr 2014 20:46

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