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Channel noise in excitable neuronal membranes

Manwani, Amit and Steinmetz, Peter N. and Koch, Christof (2000) Channel noise in excitable neuronal membranes. Advances in Neural Information Processing Systems , 12 . pp. 143-149. ISSN 1049-5258. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103247343

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Abstract

Stochastic fluctuations of voltage-gated ion channels generate current and voltage noise in neuronal membranes. This noise may be a critical determinant of the efficacy of information processing within neural systems. Using Monte-Carlo simulations, we carry out a systematic investigation of the relationship between channel kinetics and the resulting membrane voltage noise using a stochastic Markov version of the Mainen-Sejnowski model of dendritic excitability in cortical neurons. Our simulations show that kinetic parameters which lead to an increase in membrane excitability (increasing channel densities, decreasing temperature) also lead to an increase in the magnitude of the sub-threshold voltage noise. Noise also increases as the membrane is depolarized from rest towards threshold. This suggests that channel fluctuations may interfere with a neuron’s ability to function as an integrator of its synaptic inputs and may limit the reliability and precision of neural information processing.


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http://books.nips.cc/papers/files/nips12/0143.pdfPublisherArticle
Additional Information:This work was funded by NSF, NIMH and the Sloan Center for Theoretical Neuroscience. We thank our collaborators Michael London, Idan Segev and Yosef Yarom for their invaluable suggestions.
Group:Koch Laboratory, KLAB
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Record Number:CaltechAUTHORS:20130816-103247343
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103247343
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40569
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:16 Jan 2008 00:41
Last Modified:27 Aug 2013 22:27

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