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Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects

Saenz, Melissa and Lewis, Lindsay B. and Huth, Alexander G. and Fine, Ione and Koch, Christof (2008) Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects. Journal of Neuroscience, 28 (20). pp. 5141-5148. ISSN 0270-6474. PMCID PMC3165167. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103349452

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Abstract

Using functional magnetic resonance imaging, we found that cortical visual motion area MT+/V5 responded to auditory motion in two rare subjects who had been blind since early childhood and whose vision was partially recovered in adulthood. Visually normal control subjects did not show similar auditory responses. These auditory responses in MT+ were specific to motion compared with other complex auditory stimuli including frequency sweeps and speech. Thus, MT+ developed motion-specific responses to nonvisual input, suggesting that cross-modal plasticity can be influenced by the normal functional specialization of a cortical region. Regarding sight recovery after early blindness, our results further demonstate that cross-modal responses coexist with regained visual responses within the visual cortex.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/​JNEUROSCI.0803-08.2008 DOIArticle
http://www.jneurosci.org/content/28/20/5141.abstractPublisherArticle
http://www.jneurosci.org/content/28/20/5141/suppl/DC1PublisherSupplemental material
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165167/PubMed CentralArticle
Additional Information:Received Nov. 27, 2007; revised March 25, 2008; accepted March 26, 2008. This work was supported by the Gordon and Betty Moore Foundation, the Mind Science Foundation, the Caltech Summer Undergraduate Research Fellowships program, the National Institutes of Health, and the National Science Foundation. We thank our study participants, in particular M.M. and M.S., and also thank Ulrik Beierholm for help with the sparse MRI pulse sequence design.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
Mind Science FoundationUNSPECIFIED
Caltech Summer Undergraduate Research Fellowship ProgramUNSPECIFIED
National Institutes of HealthUNSPECIFIED
National Science FoundationUNSPECIFIED
Subject Keywords:multisensory; plasticity; blindness; motion; human; MT; V5
PubMed Central ID:PMC3165167
Record Number:CaltechAUTHORS:20130816-103349452
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103349452
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40653
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:16 May 2008 00:57
Last Modified:03 Apr 2014 20:34

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