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The action of the corticofugal pathway on sensory thalamic nuclei: A hypothesis

Koch, Christof (1987) The action of the corticofugal pathway on sensory thalamic nuclei: A hypothesis. Neuroscience, 23 (2). pp. 399-406. ISSN 0306-4522. http://resolver.caltech.edu/CaltechAUTHORS:20130816-103350840

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Abstract

The N-methyl-D-aspartate receptor has recently attracted great interest due to its nonlinear current-voltage behavior. In order to evoke a large depolarizing postsynaptic current, the synaptic-induced conductance change must be paired with a postsynaptic depolarization. This temporally tuned AND gate could underlie a number of different operations throughout the nervous system. We propose that the synapses made by the optical nerve onto projection cells in the mammalian dorsal lateral geniculate nucleus are of the N-methyl-D-aspartate type. [In this Commentary, we have pooled data regarding sensory thalamic nuclei from a number of different mammalian species. Unless otherwise mentioned, we have referred to the dorsal division of the cat lateral geniculate nucleus.] About half of all synapses in these cells--located almost exclusively in the peripheral two-thirds of the dendritic tree--are associated with axons originating in layer VI of visual cortex. It then follows that the massive corticogeniculate pathway controls the gain of the retinogeniculate pathway via its action on the N-methyl-D-aspartate receptors. Thus, near-simultaneous activation of the retinal and the cortical input will transiently enhance the geniculate cell response. Generalizing to other thalamic sensory nuclei, afferent information will be routed through the thalamus and on to the cortex as long as cortical activity is congruent with sensory input to the thalamus. Experimental evidence argues for such a mechanism to control the gain of the somatosensory input to the ventrobasal thalamic nucleus.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0306-4522(87)90064-9DOIArticle
http://www.sciencedirect.com/science/article/pii/0306452287900649PublisherArticle
Additional Information:(Accepted 22 June 1987). I thank Drs Francis Crick, Murray Sherman and David Van Essen for always lending a receptive ear to my speculations. This research was supported by the Charles Lee Powell Foundation and the Boeing Faculty Development Fund.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
Charles Lee Powell FoundationUNSPECIFIED
Boeing Faculty Development FundUNSPECIFIED
Subject Keywords: APV, amino-phosphonovalerate; EPSP, excitatory postsynaptic potential; LGN, lateral geniculate nucleus; NMDA, N-methyl-d-aspartate
Record Number:CaltechAUTHORS:20130816-103350840
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130816-103350840
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:40658
Collection:CaltechAUTHORS
Deposited By: KLAB Import
Deposited On:15 Jul 2008 22:16
Last Modified:13 Sep 2013 19:09

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