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Magnification of Genes Coding for Ribosomal RNA in Saccharomyces cerevisiae

Kaback, David B. and Halvorson, Harlyn O. (1977) Magnification of Genes Coding for Ribosomal RNA in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America, 74 (3). pp. 1177-1180. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:KABpnas77

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Abstract

When a strain of Saccharomyces cerevisiae monosomic for chromosome I and initially deficient for 25% of the genes coding for ribosomal RNA is repeatedly subcultured, the number of these genes increases to and remains stable at the number in the wild type. This strain shows 2:2; viable: inviable first division segregation and hemizygosity for the ade1 gene (a chromosome I marker), evidence that the strain is still monosomic for chromosome I. The increase in the number of genes coding for ribosomal RNA in yeast may be analogous to the magnification of the ribosomal RNA genes in Drosophila melanogaster bobbed mutants.


Item Type:Article
Additional Information:Copyright © 1977 by the National Academy of Sciences Communicated by S. Spiegelman, December 17, 1976 We thank Dr. Jeremy Bruenn for providing the initial stock of X1221a-7c. We also thank Dr. Stephen Sogin for valuable discussions. D.B.K. was supported by a USPHS Predoctoral Traineeship. This work was supported by Grant GM 18904-05 from the National Institutes of Health.
Subject Keywords:yeast; chromosome I monosome; DNA coding for rRNA
Record Number:CaltechAUTHORS:KABpnas77
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:KABpnas77
Alternative URL:http://www.pnas.org/cgi/content/abstract/74/3/1177
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4693
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:03 Sep 2006
Last Modified:26 Dec 2012 09:00

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