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A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction

Wu, Chun-Fang and Ganetzky, Barry and Jan, Lily Yeh and Jan, Yuh-Nung and Benzer, Seymour (1978) A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction. Proceedings of the National Academy of Sciences of the United States of America, 75 (8). pp. 4047-4051. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:WUCpnas78

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Abstract

A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired. Larvae and adults are rapidly paralyzed at restrictive temperatures; they recover rapidly when the temperature is decreased. The mutant gene is recessive and is located on the second chromosome at map position 56.


Item Type:Article
Additional Information:Copyright © 1978 by the National Academy of Sciences Contributed by Seymour Benzer, May 26, 1978 We thank our colleagues for constant comment, particularly Lawrence Kauvar and Duncan Byers. This work was supported by National Science Foundation Grant PCM73-01972. C-F.W., B.G., Y-N.J., and L.Y.J. held fellowships from, respectively, the Spencer, Jane Coffin Childs, and Muscular Dystrophy Foundations and the National Institutes of Health.
Subject Keywords:neurogenetics; paralysis; action potential
Record Number:CaltechAUTHORS:WUCpnas78
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:WUCpnas78
Alternative URL:http://www.pnas.org/cgi/content/abstract/75/8/4047
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:4747
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:05 Sep 2006
Last Modified:26 Dec 2012 09:01

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