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Robust efficiency and actuator saturation explain healthy heart rate control and variability

Li, Na and Cruz, Jerry and Chien, Chenghao Simon and Sojoudi, Somayeh and Recht, Benjamin and Stone, David and Csete, Marie and Bahmiller, Daniel and Doyle, John C. (2014) Robust efficiency and actuator saturation explain healthy heart rate control and variability. Proceedings of the National Academy of Sciences of the United States of America, 111 (33). E3476-E3485. ISSN 0027-8424. PMCID PMC4143073. http://resolver.caltech.edu/CaltechAUTHORS:20140805-091023982

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Abstract

The correlation of healthy states with heart rate variability (HRV) using time series analyses is well documented. Whereas these studies note the accepted proximal role of autonomic nervous system balance in HRV patterns, the responsible deeper physiological, clinically relevant mechanisms have not been fully explained. Using mathematical tools from control theory, we combine mechanistic models of basic physiology with experimental exercise data from healthy human subjects to explain causal relationships among states of stress vs. health, HR control, and HRV, and more importantly, the physiologic requirements and constraints underlying these relationships. Nonlinear dynamics play an important explanatory role––most fundamentally in the actuator saturations arising from unavoidable tradeoffs in robust homeostasis and metabolic efficiency. These results are grounded in domain-specific mechanisms, tradeoffs, and constraints, but they also illustrate important, universal properties of complex systems. We show that the study of complex biological phenomena like HRV requires a framework which facilitates inclusion of diverse domain specifics (e.g., due to physiology, evolution, and measurement technology) in addition to general theories of efficiency, robustness, feedback, dynamics, and supporting mathematical tools.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1401883111DOIArticle
http://www.pnas.org/content/111/33/E3476.fullPublisherArticle
http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1401883111/-/DCSupplementalPublisherSupporting Information
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143073/PubMed CentralArticle
Additional Information:Copyright © 2014 National Academy of Sciences. Edited by Michael S. Gazzaniga, University of California, Santa Barbara, CA, and approved June 27, 2014 (received for review January 30, 2014). Published online before print August 4, 2014, doi: 10.1073/pnas.1401883111. We thank Pamela B. Pesenti for her gift in establishing the John G. Braun Professorship, which supported this research, and Philips for providing equipment used in the experiments. The research progress has been presented and discussed at several meetings, including the International Conference on Complexity in Acute Illness of the Society for Complexity in Acute Illness (SCAI). Comments from many SCAI members greatly influenced this paper. We also thank the athletes who were the subjects for this study. The theoretical aspects of this work and the connections with other complex systems challenges were supported in part by Air Force Office of Scientific Research and National Science Foundation. Preliminary exploration in this research direction was funded by Pfizer, National Institutes of Health (R01 GM078992), and the Institute of Collaborative Biotechnologies (ARO W911NF-09-D-0001). Author contributions: N.L., J.C., B.R., and J.C.D. designed research; N.L., J.C., C.S.C., B.R., D.B., and J.C.D. performed research; N.L., J.C., S.S., B.R., and J.C.D. contributed new reagents/analytic tools; N.L., J.C., C.S.C., S.S., and J.C.D. analyzed data; and N.L., D.S., M.C., and J.C.D. wrote the paper. The authors declare no conflict of interest. This Direct Submission article had a prearranged editor. This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1401883111/-/DCSupplemental.
Funders:
Funding AgencyGrant Number
John G. Braun Professorship, CaltechUNSPECIFIED
Air Force Office of Scientific Research (AFOSR)UNSPECIFIED
NSFUNSPECIFIED
PfizerUNSPECIFIED
NIHR01 GM078992
Army Research Office (ARO)W911NF-09-D-0001
Subject Keywords:system identification; optimal control; respiratory sinus arrhythmia
PubMed Central ID:PMC4143073
Record Number:CaltechAUTHORS:20140805-091023982
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140805-091023982
Official Citation:Na Li, Jerry Cruz, Chenghao Simon Chien, Somayeh Sojoudi, Benjamin Recht, David Stone, Marie Csete, Daniel Bahmiller, and John C. Doyle Robust efficiency and actuator saturation explain healthy heart rate control and variability PNAS 2014 111 (33) E3476-E3485; published ahead of print August 4, 2014, doi:10.1073/pnas.1401883111
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:47960
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Aug 2014 16:30
Last Modified:15 Oct 2015 23:35

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