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Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal Subsets

Hong, Weizhe and Kim, Dong-Woo and Anderson, David J. (2014) Antagonistic Control of Social versus Repetitive Self-Grooming Behaviors by Separable Amygdala Neuronal Subsets. Cell, 158 (6). pp. 1348-1361. ISSN 0092-8674. http://resolver.caltech.edu/CaltechAUTHORS:20140909-173728039

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Abstract

Animals display a range of innate social behaviors that play essential roles in survival and reproduction. While the medial amygdala (MeA) has been implicated in prototypic social behaviors such as aggression, the circuit-level mechanisms controlling such behaviors are not well understood. Using cell-type-specific functional manipulations, we find that distinct neuronal populations in the MeA control different social and asocial behaviors. A GABAergic subpopulation promotes aggression and two other social behaviors, while neighboring glutamatergic neurons promote repetitive self-grooming, an asocial behavior. Moreover, this glutamatergic subpopulation inhibits social interactions independently of its effect to promote self-grooming, while the GABAergic subpopulation inhibits self-grooming, even in a nonsocial context. These data suggest that social versus repetitive asocial behaviors are controlled in an antagonistic manner by inhibitory versus excitatory amygdala subpopulations, respectively. These findings provide a framework for understanding circuit-level mechanisms underlying opponency between innate behaviors, with implications for their perturbation in psychiatric disorders.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cell.2014.07.049DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867414010393PublisherArticle
http://dx.doi.org/10.1016/j.cell.2014.07.049OtherSupplemental Material
Additional Information:Copyright © 2014 Elsevier Inc. Received: March 4, 2014. Revised: May 27, 2014. Accepted: July 17, 2014. Published: September 11, 2014. We thank X. Wang, X. Da, M. McCardle, R. Robertson, and C. Park for tech- nical assistance, T. Anthony for the ChR2 virus, the Caltech GEMS and animal facility for maintaining mice, M. Zelikowsky, H. Cai, and K. Asahina for commenting on the manuscript, and members of the D.J.A. laboratory for discussions. W.H. is a Helen Hey Whitney Fellow. D.J.A. is a Howard Hughes Medical Institute Investigator and a Paul G. Allen Distinguished Investigator. This work was supported in part by NIH grants MH085082 and MH070053, and a grant from Gerald Fischbach and the Simons Foundation. W.H. and D.J.A. designed the experiments. W.H. performed most of the experiments. D.-W.K. performed electrophysiological recordings. D.J.A. supervised the project. W.H. and D.J.A wrote the manuscript.
Funders:
Funding AgencyGrant Number
NIHMH085082
NIHMH070053
Gerald FischbachUNSPECIFIED
Simons FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Paul G. Allen Family FoundationUNSPECIFIED
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Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20140909-173728039
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ID Code:49515
Collection:CaltechAUTHORS
Deposited By: Joy Painter
Deposited On:11 Sep 2014 16:27
Last Modified:11 Sep 2014 16:27

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