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Single-Cell Responses to Face Adaptation in the Human Medial Temporal Lobe

Quiroga, Rodrigo Quian and Kraskov, Alexander and Mormann, Florian and Fried, Itzhak and Koch, Christof (2014) Single-Cell Responses to Face Adaptation in the Human Medial Temporal Lobe. Neuron, 84 (2). pp. 363-369. ISSN 0896-6273. PMCID PMC42106374. http://resolver.caltech.edu/CaltechAUTHORS:20141007-105137786

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Abstract

We used a face adaptation paradigm to bias the perception of ambiguous images of faces and study how single neurons in the human medial temporal lobe (MTL) respond to the same images eliciting different percepts. The ambiguous images were morphs between the faces of two familiar individuals, chosen because at least one MTL neuron responded selectively to one but not to the other face. We found that the firing of MTL neurons closely followed the subjects’ perceptual decisions—i.e., recognizing one person or the other. In most cases, the response to the ambiguous images was similar to the one obtained when showing the pictures without morphing. Altogether, these results show that many neurons in the medial temporal lobe signal the subjects’ perceptual decisions rather than the visual features of the stimulus.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2014.09.006DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627314007946PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210637/PubMed CentralArticle
ORCID:
AuthorORCID
Mormann, Florian0000-0003-1305-8028
Koch, Christof0000-0001-6482-8067
Additional Information:© 2014 The Authors This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). Accepted: August 29, 2014; Published: September 25, 2014. Available online 25 September 2014. We thank all patients for their participation and E. Behnke, T. Fields, A. Postolova, and K. Laird for technical assistance. This work was supported by grants from NINDS, EPSRC, MRC, the NIMH, and the G. Harold & Leila Y. Mathers Charitable Foundation. Author Contributions: C.K., I.F., A.K., and R.Q.Q. designed the paradigm; I.F. performed the surgeries; A.K. and F.M. collected the electrophysiological data; R.Q.Q. analyzed the data and wrote the paper; and all authors discussed the results and commented on the manuscript. R.Q.Q. and A.K. contributed equally to the study.
Group:KLAB, Koch Laboratory
Funders:
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Engineering and Physical Sciences Research Council (EPSRC)UNSPECIFIED
Medical Research Council (UK)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
G. Harold and Leila Y. Mathers Charitable FoundationUNSPECIFIED
NIHUNSPECIFIED
PubMed Central ID:PMC42106374
Record Number:CaltechAUTHORS:20141007-105137786
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141007-105137786
Official Citation:Rodrigo Quian Quiroga, Alexander Kraskov, Florian Mormann, Itzhak Fried, Christof Koch, Single-Cell Responses to Face Adaptation in the Human Medial Temporal Lobe, Neuron, Volume 84, Issue 2, 22 October 2014, Pages 363-369, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2014.09.006. (http://www.sciencedirect.com/science/article/pii/S0896627314007946)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:50231
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Oct 2014 21:48
Last Modified:08 Feb 2017 16:58

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