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Independent, Reciprocal Neuromodulatory Control of Sweet and Bitter Taste Sensitivity during Starvation in Drosophila

Inagaki, Hidehiko K. and Panse, Ketaki M. and Anderson, David J. (2014) Independent, Reciprocal Neuromodulatory Control of Sweet and Bitter Taste Sensitivity during Starvation in Drosophila. Neuron, 84 (4). pp. 806-820. ISSN 0896-6273. PMCID PMC4365050. http://resolver.caltech.edu/CaltechAUTHORS:20141110-091624067

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Abstract

An organism’s behavioral decisions often depend upon the relative strength of appetitive and aversive sensory stimuli, the relative sensitivity to which can be modified by internal states like hunger. However, whether sensitivity to such opposing influences is modulated in a unidirectional or bidirectional manner is not clear. Starved flies exhibit increased sugar and decreased bitter sensitivity. It is widely believed that only sugar sensitivity changes, and that this masks bitter sensitivity. Here we use gene- and circuit-level manipulations to show that sweet and bitter sensitivity are independently and reciprocally regulated by starvation in Drosophila. We identify orthogonal neuromodulatory cascades that oppositely control peripheral taste sensitivity for each modality. Moreover, these pathways are recruited at increasing hunger levels, such that low-risk changes (higher sugar sensitivity) precede high-risk changes (lower sensitivity to potentially toxic resources). In this way, state-intensity-dependent, reciprocal regulation of appetitive and aversive peripheral gustatory sensitivity permits flexible, adaptive feeding decisions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2014.09.032DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627314008526PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365050PubMed CentralArticle
Additional Information:© 2014 Elsevier B.V. Accepted: September 15, 2014; published: October 30, 2014. Fly stocks were generously provided by the Bloomington Stock Center; by the VDRC Stock Center; by the Drosophila RNAi Screening Center; and by Drs. K. Yu, J.W. Wang, P. Shen, J.H. Park, M.J. Pankratz, G.M. Rubin, B. Pfeiffer, J.H. Simpson, L.L. Looger, K. Scott, C. Montell, H. Amrein, G.S. Suh, H. Keshishian, P.A. Garrity, T. Kitamoto, H. Ishimoto, and B.J. Dickson. We also thank Dr. D. R. Nässel for anti-sNPF precursor serum. H.K.I. is supported by the Nakajima Foundation. D.J.A. is an investigator of the Howard Hughes Medical Institute. This work was supported in part by NIH grant 1RO1 DA031389 to D.J.A.
Funders:
Funding AgencyGrant Number
Nakajima FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIH1RO1 DA031389
PubMed Central ID:PMC4365050
Record Number:CaltechAUTHORS:20141110-091624067
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141110-091624067
Official Citation:Hidehiko K. Inagaki, Ketaki M. Panse, David J. Anderson, Independent, Reciprocal Neuromodulatory Control of Sweet and Bitter Taste Sensitivity during Starvation in Drosophila, Neuron, Volume 84, Issue 4, 19 November 2014, Pages 806-820, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2014.09.032. (http://www.sciencedirect.com/science/article/pii/S0896627314008526)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51485
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:10 Nov 2014 21:48
Last Modified:21 Jul 2017 15:39

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