Hall , James E. and Mead, C. A. and Szabo, Gabor (1973) A barrier model for current flow in lipid bilayer membranes. Journal of Membrane Biology, 11 (1). pp. 75-97. ISSN 0022-2631. http://resolver.caltech.edu/CaltechAUTHORS:20150109-143557131
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The shape of the energy barrier inside thin, insulating membranes can be an important factor in determining the detailed behavior of transmembrane ionic flows. In particular, a model is developed in which the shape of the barrier is expected to have direct influence on such experimentally important membrane properties as: (a) the shape of the current-voltage relation; (b) the dependence of zero current conductivity on asymmetric concentrations; (c) the dependence of the rectification ratio on the concentration ratio. Current-voltage curves were measured for a wide range of symmetrical and asymmetrical concentrations in black lipid (phosphatidyl ethanolamine) films in the presence of nonactin and potassium. A single barrier shape was found to describe accurately the experimental results in terms of the model.
|Additional Information:||© 1973 Springer-Verlag. Received 7 April 1972. We wish to thank Dr. Stuart McLaughlin and Professors Max Delbrück and George Eisenman for critical readings of the manuscript. J. E. H. thanks the Sloan Foundation for support. G. S. acknowledges the support of USPHS Grant No. NS 09931-02 and NSF Grant No. GB 30835.|
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|Deposited By:||Kristin Buxton|
|Deposited On:||09 Jan 2015 23:13|
|Last Modified:||10 Jan 2015 03:57|
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