Ten Significant Events
1) Proposal of the Molecular Clock
Emile Zuckerkandl and Linus Pauling, "Evolutionary Divergence
and Convergence in Proteins," in Evolving Genes and Proteins,
eds. V. Bryson and H. Vogel (New York: Academic Press, 1965).
2) Original Proposal of the Neutral Theory by Kimura
Motoo Kimura, "Evolutionary Rate at the Molecular Level,"
Nature 217 (1968), 624-626.
3) Non-Darwinian Evolution by King and Jukes
Jack King and Thomas Jukes, "Non-Darwinian Evolution,"
Science 164 (1969), 788-798.
4) Proposal of the Near Neutral Theory
Tomoko Ohta, "Slightly Deleterious Mutant Substitutions in
Evolution," Nature 246 (1973), 96-98.
5) Apparently Uniform Heterozygosity at the Protein Level was
raised as a Problem of the Neutral Theory
R. C. Lewontin, The Genetic Basis of Evolutionary Change.
(New York, NY: Columbia University Press, 1974).
6) Rapid Evolution of Pseudogenes.
T. Miyata and T. Yasunaga, "Rapidly evolving mouse alpha
globin related pseudogene and its evolutionary history," PNAS
78 (1981), 450-453.
7) Comparative Study of Synonymous and Nonsynonymous
J. H. McDonald and M. Kreitman, "Adaptive protein evolution
at the AHD locus in Drosophila," Nature 351 (1991), 652-654.
8) Rapid Evolution at Nonsynonymous Sites in Small
N. A. Moran, "Accelerated evolution and Muller's Ratchet in
Endosymbiotic bacteria," PNAS 93 (1996), 2873-2878.
9) Detection of Positive Selection by Comparing Nonsynonymous
and Synonymous Substitutions.
A. L. Hughes and M. Nei, "Patter of nucleotide substitutions
at major histocompatibility complex class I loci reveals
overdominant selection," Nature 335 (1988), 167-170.
10) Sequence Turnover at a Regulatory Element.
M. Z. Ludwig, et al., "Evidence for stabilizing selection in
a eukaryotic enhancer element," Nature 403 (2000), 564-567.
-- Tomoko Ohta, May 26, 2002
James Crow's Top Ten Events
Here are what I would regard as the top ten events in the
history of molecular evolution, and the neutral theory in
1. Freese and Sueoka -- forerunners of the neutral theory.
2. Infinite allele model.
3. Pauling and Zuckerkandl -- a molecular clock
4. Kimura's 1968 paper
5. King and Jukes 1969 paper
6. Kimura and Ewens showing the time till loss or fixation
of a mutation
7. Nearly neutral mutations -- Ohta
8. Coalescence theory -- Kingman
9. Use neutrality as a null hypothesis and to construct trees.
10. Y chromosome and mitochondrial DNA in human evolution,
especially to study
sex differences in migration
-- Michael Dietrich, February 6, 2003