Molecular Evolution Activities

Top Ten Publications or Events
What do you believe were the ten most significant publications and/or events in the development of the history of neutral molecular evolution? Feel free to add any commentary on your proposed list or the lists of others.
-- Michael Dietrich

Ten Significant Events
1) Proposal of the Molecular Clock Emile Zuckerkandl and Linus Pauling, "Evolutionary Divergence and Convergence in Proteins," in Evolving Genes and Proteins, eds. V. Bryson and H. Vogel (New York: Academic Press, 1965). pp. 97-166.

2) Original Proposal of the Neutral Theory by Kimura Motoo Kimura, "Evolutionary Rate at the Molecular Level," Nature 217 (1968), 624-626.

3) Non-Darwinian Evolution by King and Jukes Jack King and Thomas Jukes, "Non-Darwinian Evolution," Science 164 (1969), 788-798.

4) Proposal of the Near Neutral Theory Tomoko Ohta, "Slightly Deleterious Mutant Substitutions in Evolution," Nature 246 (1973), 96-98.

5) Apparently Uniform Heterozygosity at the Protein Level was raised as a Problem of the Neutral Theory R. C. Lewontin, The Genetic Basis of Evolutionary Change. (New York, NY: Columbia University Press, 1974).

6) Rapid Evolution of Pseudogenes. T. Miyata and T. Yasunaga, "Rapidly evolving mouse alpha globin related pseudogene and its evolutionary history," PNAS 78 (1981), 450-453.

7) Comparative Study of Synonymous and Nonsynonymous Divergence Patterns. J. H. McDonald and M. Kreitman, "Adaptive protein evolution at the AHD locus in Drosophila," Nature 351 (1991), 652-654.

8) Rapid Evolution at Nonsynonymous Sites in Small Populations. N. A. Moran, "Accelerated evolution and Muller's Ratchet in Endosymbiotic bacteria," PNAS 93 (1996), 2873-2878.

9) Detection of Positive Selection by Comparing Nonsynonymous and Synonymous Substitutions. A. L. Hughes and M. Nei, "Patter of nucleotide substitutions at major histocompatibility complex class I loci reveals overdominant selection," Nature 335 (1988), 167-170.

10) Sequence Turnover at a Regulatory Element. M. Z. Ludwig, et al., "Evidence for stabilizing selection in a eukaryotic enhancer element," Nature 403 (2000), 564-567.

-- Tomoko Ohta, May 26, 2002

James Crow's Top Ten Events
Here are what I would regard as the top ten events in the history of molecular evolution, and the neutral theory in particular.

1. Freese and Sueoka -- forerunners of the neutral theory.

2. Infinite allele model.

3. Pauling and Zuckerkandl -- a molecular clock

4. Kimura's 1968 paper

5. King and Jukes 1969 paper

6. Kimura and Ewens showing the time till loss or fixation of a mutation

7. Nearly neutral mutations -- Ohta

8. Coalescence theory -- Kingman

9. Use neutrality as a null hypothesis and to construct trees.

10. Y chromosome and mitochondrial DNA in human evolution, especially to study sex differences in migration

-- Michael Dietrich, February 6, 2003