Author :
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Gauldie, R. W.
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Year :
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1996
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Title :
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Testing neutral theorists: Revisiting heterozygosities at the phosphoglucomutase locus and glucose phosphate isomerase locus
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Journal :
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Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology
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Volume :
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115
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Issue :
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1
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Pages :
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47-56
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Date :
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Sep
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Short Title :
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Testing neutral theorists: Revisiting heterozygosities at the phosphoglucomutase locus and glucose p
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Alternate Journal :
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Comp. Biochem. Physiol. B-Biochem. Mol. Biol.
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Custom 2 :
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ISI:A1996VK16000007
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Abstract :
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A previous examination (6) of the distribution of frequencies of protein polymorphisms at the phosphoglucomutase and glucose phosphate isomerase loci showed a statistical bias against both loci being simultaneously polymorphic. A rebuttal of these findings based on a neutral theory approach to analysis has been published that argues against such a bias. The neutral theory approach is disputed on the grounds that 1) a fundamentally different data set was used and 2) that the data was skewed by the use of inappropriate transforms: Upgrading the original data with new observations confirms the original observation of a statistical bias against both loci being simultaneously polymorphic. A model based on different chemistries associated with different polymorphism can explain the observed distribution of PGM and GPI heterozygosities.
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Notes :
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Times Cited: 0
VK160
COMP BIOCHEM PHYSIOL PT B
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| -- contributed by John Beatty, March 29, 2002 |
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