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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Huai, H.;Woodruff, R. C.
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Year :
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1997
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Title :
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Clusters of identical new mutations can account for the "overdispersed" molecular clock
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Journal :
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Genetics
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Volume :
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147
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Issue :
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1
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Pages :
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339-48
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Short Title :
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Clusters of identical new mutations can account for the "overdispersed" molecular clock
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Custom 3 :
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97432813
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Abstract :
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Germ-cell mutations may occur during meiosis, giving rise to independent mutant gametes in a Poisson process, or before meiosis, giving rise to multiple copies of identical mutant gametes at a much higher probability than the Poisson expectation. We report that the occurrence of these early premeiotic clusters of new identical mutant alleles increases the variance-to-mean ratio of mutation rate (R(u) > 1). This leads to an expected variance-to-mean ratio (R(t)) of the molecular clock that is always greater than one and may cover the observed range of R(t) values. Hence, the molecular clock may not be over-dispersed based on this new mutational model that includes clusters. To get a better estimation of R(u) and R(t), one needs measurements of the intrageneration variation of reproductive success (Nt/Ne(i)), population dynamics (ki), and the proportion of new mutations that occur in clusters (rc), especially those formed before germ-cell differentiation.
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| | -- contributed by John Beatty, March 29, 2002 |
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