Molecular Evolution Activities
 

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Ina, Y.

Year :

1996

Title :

Pattern of synonymous and nonsynonymous substitutions: An indicator of mechanisms of molecular evolution

Journal :

Journal of Genetics

Volume :

75

Issue :

1

Pages :

91-115

Date :

Apr

Short Title :

Pattern of synonymous and nonsynonymous substitutions: An indicator of mechanisms of molecular evolu

Alternate Journal :

J. Genet.

Custom 2 :

ISI:A1996VT92600011

Abstract :

Comparison of numbers of synonymous and nonsynonymous substitutions is useful for understanding mechanisms of molecular evolution. In this paper, I examine the statistical properties of six methods of estimating numbers of synonymous and nonsynonymous substitutions. The six methods are Miyata and Yasunaga's (MY) method; Nei and Gojobori's (NG) method; Li, Wu and Luo's (LWL) method; Pamilo, Bianchi and Li's (PBL) method; and Ina's (Ina) two methods. When the transition/transversion bias at the mutation level is strong, the numbers of synonymous and nonsynonymous substitutions are estimated more accurately by the PBL and Ina methods than by the NG, MY and LWL methods. When the nucleotide-frequency bias is strong and distantly related sequences are compared, all the six methods give underestimates of the number of synonymous substitutions. The concept of synonymous and nonsynonymous categories is also useful for analysis of DNA polymorphism data.

Notes :

Times Cited: 8 VT926 J GENET
 -- contributed by John Beatty, March 29, 2002