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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Nachman, M. W.
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Year :
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1998
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Title :
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Y chromosome variation of mice and men
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Journal :
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Molecular Biology and Evolution
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Volume :
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15
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Issue :
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12
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Pages :
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1744-1750
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Date :
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Dec
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Short Title :
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Y chromosome variation of mice and men
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Alternate Journal :
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Mol. Biol. Evol.
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Custom 2 :
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ISI:000077555400016
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Abstract :
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DNA sequences from the nonrecombining portion of the Y chromosome were compared with autosomal and X-linked sequences from mice and humans to test the neutral prediction that ratios of polymorphism to divergence are the same for different genes. Intraspecific variation within Mus domesticus was compared with divergence between M. domesticus and Mus caroli for Sip. a region 5' to Sn and four X-linked genes, Hprt, Plp, Amg, and Glra2. None of these comparisons revealed significantly reduced variation on the Y chromosome. Intraspecific variation within humans was compared with divergence between humans and chimpanzees for three Y-linked Loci (Zfy) the YAP region, and the Sry region), seven X-linked loci (Il2rg, Plp. Hprt, Gk. Ids, Pdha1, and Dmd), and the P-globin locus on chromosome ii. In these comparisons, the observed level of variation on the human Y chromosome was slightly lower than expected, but was significantly lower in only one case (Sry region us. Dmd). These results suggest that the levels of variability on the Y chromosome in mice and humans are close to expected values given the effective population size and mutation rates for these loci. There is at most only a modest reduction in variability that may be attributed to natural selection (either genetic hitchhiking or background selection).
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Notes :
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Times Cited: 11
148VZ
MOL BIOL EVOL
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| | -- contributed by John Beatty, March 29, 2002 |
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