Molecular Evolution Activities
 

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Nachman, M. W.

Year :

1998

Title :

Deleterious mutations in animal mitochondrial DNA

Journal :

Genetica

Volume :

103

Pages :

61-69

Short Title :

Deleterious mutations in animal mitochondrial DNA

Alternate Journal :

Genetica

Custom 2 :

ISI:000075404900007

Abstract :

A simple neutral model predicts that the ratio of non- synonymous to synonymous fixed differences between species will be the same as the ratio of non-synonymous to synonymous polymorphisms within species. This prediction is tested with existing mitochondrial datasets from 25 animal species. In slightly over half of the studies, the ratio of replacement to silent polymorphisms within species is significantly greater than the ratio of replacement to silent fixed differences between species. These observations are best explained by a substantial number of mildly deleterious amino acid mutations that contribute to heterozygosity but rarely become fixed.

Notes :

Times Cited: 3 SI 110WQ GENETICA
 -- contributed by John Beatty, March 29, 2002