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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Ohta, T.
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Year :
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1995
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Title :
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Gene Conversion Vs Point Mutation in Generating Variability at the Antigen Recognition Site of Major Histocompatibility Complex Loci
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Journal :
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Journal of Molecular Evolution
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Volume :
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41
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Issue :
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2
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Pages :
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115-119
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Date :
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Aug
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Short Title :
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Gene Conversion Vs Point Mutation in Generating Variability at the Antigen Recognition Site of Major
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Alternate Journal :
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J. Mol. Evol.
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Custom 2 :
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ISI:A1995RH80800002
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Abstract :
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In order to assess the roles of gene conversion followed by natural selection and balancing selection for point mutations in polymorphisms at major histocompatibility complex (MHC) loci, DNA sequences of several mammalian taxa were analyzed. Synonymous and nonsynonymous diversities were estimated separately for the antigen recognition site (ARS) and the remaining region of class I and class II genes. In some sequence pairs, the number of nonsynonymous substitutions exceeds that of synonymous substitutions at the ARS. This result indicates that some kind of balancing selection for point mutation is operating. In other sequence pairs (particularly of bovine and of rabbit), the number of synonymous substitutions at the ARS exceeds the same number at the remaining region. This result indicates that gene conversion involving a short region followed by natural selection is important. In general, a combination of gene conversion, point mutation, natural selection and random drift is thought to have contributed to polymorphisms.
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Notes :
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Times Cited: 18
RH808
J MOL EVOL
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| | -- contributed by John Beatty, March 29, 2002 |
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