

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 19732001. 
Author :

Phelps, F. M.

Year :

1995

Title :

A Model for the Evolution of the Genome  the Effect of Stochasticity on Genetic Loads

Journal :

Ima Journal of Mathematics Applied in Medicine and Biology

Volume :

12

Issue :

1

Pages :

111

Short Title :

A Model for the Evolution of the Genome  the Effect of Stochasticity on Genetic Loads

Alternate Journal :

IMA J. Math. Appl. Med. Biol.

Custom 2 :

ISI:A1995TE03200001

Abstract :

In this paper a general model is given for the evolution of the genome incorporating stochastic factors. The model is applied to the substitutional genetic load problem. All of the major hard selection load formulae in the literature are extended and, where necessary, corrected (for stochasticity). Turning to rank selection, formulae for stochastic factors are also corrected and harmful mutations included. A simple formula for the selection coefficient as a function of the nonneutral substitution rate and the mutation profile is obtained. Further, it is noted that the formulae derived also apply (for different parameter values) to the mutation load, thus unifying the two loads under a single theory. A general formula for the mutation load under hard selection is given, extending previous results. Finally, the author derives a formula showing how many harmful mutations can be effectively eliminated by rank selection and discusses its relevance to the question of the possible buildup of harmful mutations in the human gene pool due to longterm exposure to lowlevel radiation.

Notes :

Times Cited: 1
TE032
IMA J MATH APPL MED BIOL

  contributed by John Beatty, March 29, 2002 







