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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Shabalina, S. A.;Kondrashov, A. S.
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Year :
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1999
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Title :
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Pattern of selective constraint in C-elegans and C-briggsae genomes
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Journal :
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Genetical Research
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Volume :
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74
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Issue :
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1
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Pages :
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23-30
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Date :
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Aug
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Short Title :
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Pattern of selective constraint in C-elegans and C-briggsae genomes
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Alternate Journal :
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Genet. Res.
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Custom 2 :
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ISI:000082450800003
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Abstract :
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Similarity between related genomes may carry information on selective constraint in each of them. We analysed patterns of similarity between several homologous regions of Caenorhabditis elegans and C. briggsae genomes. All homologous exons are quite similar. Alignments of introns and of intergenic sequences contain long gaps, segments where similarity is low and close to that between random sequences aligned using the same parameters, and segments of high similarity. Conservative estimates of the fractions of selectively constrained nucleotides are 72%, 17% and 18% for exons, introns and intergenic sequences, respectively. This implies that the total number of constrained nucleotides within non-coding sequences is comparable to that within coding sequences, so that at least one-third of nucleotides in C. elegans and C. briggsae genomes are under strong stabilizing selection.
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Notes :
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Times Cited: 15
233WU
GENET RES
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| | -- contributed by John Beatty, March 29, 2002 |
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