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This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
Author :
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Trusov, Y. A.;Dear, P. H.
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Year :
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1996
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Title :
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A molecular clock based on the expansion of gene families
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Journal :
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Nucleic Acids Research
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Volume :
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24
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Issue :
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6
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Pages :
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995-9
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Short Title :
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A molecular clock based on the expansion of gene families
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Custom 3 :
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96184844
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Abstract :
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There is evidence to suggest that eukaryotic genomes are subject to frequent insertions and deletions of non-coding DNA. This may lead to a gradual increase or decrease in genome size, or to a dynamic equilibrium in which the overall size remains constant. We argue, however, that there is a bias favouring an accumulation of non-coding DNA in the proximity of genes. Such bias causes a progressive change in genome structure regardless of whether the overall genome size increases, decreases or remains constant. We show that this change may serve as a 'molecular clock', supplementing that provided by nucleotide substitution rates.
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| -- contributed by John Beatty, March 29, 2002 |
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