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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Woodwark, M.;Skibinski, D. O. F.;Ward, R. D.
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Year :
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1992
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Title :
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A Study of Interlocus Allozyme Heterozygosity Correlations - Implications for Neutral Theory
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Journal :
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Heredity
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Volume :
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69
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Pages :
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190-198
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Date :
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Aug
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Short Title :
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A Study of Interlocus Allozyme Heterozygosity Correlations - Implications for Neutral Theory
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Alternate Journal :
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Heredity
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Custom 2 :
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ISI:A1992JG28000013
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Abstract :
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Using a database of allozyme studies, correlations in heterozygosity between selected enzyme loci (MDH, alpha-GPDH, IDH, 6PGDH, LDH, SOD, AAT, PGM, EST, PGI) were calculated across vertebrate species. Large and positive correlations were observed with untransformed heterozygosity values. However, after transformation to correct for mean species heterozygosity, correlations were substantially reduced and median values were closer to zero. Some enzymes were more often involved in significant correlations than others, and correlations calculated across species within vertebrate classes were significant for different enzyme pairs in different classes. There was no evidence that significant correlations occurred primarily between functionally related enzymes. It is suggested that the observed correlations are best explained by variation between enzyme loci in functional constraint and effective neutral mutation rate.
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Notes :
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Times Cited: 4
2
JG280
HEREDITY
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| | -- contributed by John Beatty, March 29, 2002 |
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