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Attachment of Carbohydrate to the Variable Region of Myeloma Immunoglobulin Light Chains

Sox, Harold C., Jr. and Hood, Leroy (1970) Attachment of Carbohydrate to the Variable Region of Myeloma Immunoglobulin Light Chains. Proceedings of the National Academy of Sciences of the United States of America, 66 (3). pp. 975-982. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:SOXpnas70

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Abstract

Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence [Note: See the image of page 975 for this formatted text] Asn- _ -Ser/Thr was at the site of carbohydrate attachment in all light chains. The carbohydrate group was attached to the asparagine residue of this triplet sequence which in all five light chains was located in the variable region. The occasional occurrence of carbohydrate in myeloma light chains is seen as the consequence of a variable region mutation creating an [Note: See the image of page 975 for this formatted text] Asn- _ -Ser/Thr sequence to which carbohydrate is attached by an enzyme capable of recognizing the characteristic triplet sequence.


Item Type:Article
Additional Information:Copyright © 1970 by the National Academy of Sciences Communicated by Elvin A. Kabat, April 10, 1970 We wish to thank Dr. Victor Ginsburg for helpful advice and criticism.
Record Number:CaltechAUTHORS:SOXpnas70
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:SOXpnas70
Alternative URL:http://www.pnas.org/cgi/content/abstract/66/3/975
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5723
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:30 Oct 2006
Last Modified:26 Dec 2012 09:14

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