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Assignment of the Human and Mouse Prion Protein Genes to Homologous Chromosomes

Sparkes, Robert S. and Simon, Melvin and Cohn, Vivian H. and Fournier, R. E. K. and Lem, Janice and Klisak, Ivana and Heinzmann, Camilla and Blatt, Cila and Lucero, Michael and Mohandas, T. and DeArmond, Stephen J. and Westaway, David and Pruisner, Stanley B. and Weiner, Leslie P. (1986) Assignment of the Human and Mouse Prion Protein Genes to Homologous Chromosomes. Proceedings of the National Academy of Sciences of the United States of America, 83 (19). pp. 7358-7362. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:SPApnas86

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Abstract

Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using somatic cell hybrids. In situ hybridization studies mapped the human PrP gene to band 20p12→pter. Our results should lead to studies of genetic loci syntenic with the PrP gene, which may play a role in the pathogenesis of prion diseases or other degenerative neurologic disorders.


Item Type:Article
Additional Information:Copyright © 1986 by the National Academy of Sciences Contributed by Melvin Simon, May 27, 1986 L.P.W. was supported by the Joseph Drown Foundation and John Douglas French Foundation for Alzheimer's Disease. V.H.C. was supported by a research grant from the National Institutes of Health (T32 NS07149). R.E.K.F. was supported by a research grant from the National Institutes of Health (GM26449) and is a recipient of the American Cancer Society Research Award. S.B.P. and S.J.D. were supported by research grants from the National Institutes of Health (NS22786, AG02132, and NS14069) as well as by gifts from R.J. Reynolds Industries, Inc., Sherman Fairchild Foundation, and the John Douglas French Foundation for Alzheimer's Disease. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:scrapie; Creutzfeldt-Jakob disease; slow infections; dementia gene mapping
Record Number:CaltechAUTHORS:SPApnas86
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:SPApnas86
Alternative URL:http://www.pnas.org/cgi/content/abstract/83/19/7358
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:5725
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:30 Oct 2006
Last Modified:14 Nov 2014 19:19

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