Hyde, David R. and Mecklenburg, Kirk L. and Pollock, John A. and Vihtelic, Thomas S. and Benzer, Seymour (1990) Twenty Drosophila Visual System cDNA Clones: One is a Homolog of Human Arrestin. Proceedings of the National Academy of Sciences of the United States of America, 87 (3). pp. 1008-1012. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:HYDpnas90
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From a group of 436 Drosophila melanogaster cDNA clones, we selected 39 that are expressed exclusively or predominantly in the adult visual system. By sequence analysis, 20 of the clones appear to represent previously unreported distinct cDNAs. The corresponding transcripts are detected in the retina and optic lobes. The genes are scattered throughout the genome, some near mutations known to affect eye function. One of these clones has been identified, by sequence analysis, as the structural gene (Arr) for a Drosophila homolog of human arrestin. Vertebrate arrestin interacts with rhodopsin in phototransduction and has been associated with an autoimmune form of uveitis in primates. The presence of an arrestin homolog in Drosophila suggests that both the vertebrate and invertebrate phototransduction cascades are regulated in a similar manner.
|Additional Information:||Copyright © 1990 by National Academy of Sciences Contributed by Seymour Benzer, November 6, 1989 We thank C. Zuker and coworkers for communicating results before publication and for critical review of the manuscript. We thank Seema Shah for isolating the arrestin genomic clones and characterizing the intron/exon relationship. We also thank Christine Pham for excellent technical assistance, Fintan Steele for confirming the map positions of clones 4A11, 5B3, and 9H9, and G. Guttman for the sequence analysis program. We also thank our colleagues for their constant stimulation. This work was supported by National Science Foundation Grant DCB8409366 and National Institutes of Health Grant GM40499 to S.B., National Eye Institute Grant EY08058 and the University of Notre Dame Jesse H. Jones Faculty Research and Equipment Fund to D.R.H., a Developmental Biology Grant from the Lucille P. Markey Charitable Trust, and National Institutes of Health Postdoctoral Fellowships from the National Eye Institute to D.R.H., K.L.M., and J.A.P. The sequence reported in this paper has been deposited in the GenBank data base (accession no. M30140). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.|
|Subject Keywords:||eye; retina; photoreceptor; phototransduction; Arr gene|
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|Deposited By:||Archive Administrator|
|Deposited On:||06 Nov 2006|
|Last Modified:||26 Dec 2012 09:16|
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