Hwu, Huey Ru and Roberts, John W. and Davidson, Eric H. and Britten, Roy J. (1986) Insertion and/or Deletion of Many Repeated DNA Sequences in Human and Higher Ape Evolution. Proceedings of the National Academy of Sciences of the United States of America, 83 (11). pp. 3875-3879. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:HWUpnas86
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The total numbers of copies of two repeat families, L1 (Kpn I) and Alu, have been measured in the DNA of four higher apes by an accurate titration method. The number of members of the Alu family repeats in the four genomes are as follows: human, 910,000; chimpanzee, 330,000; gorilla, 410,000; orangutan, 580,000. For the Kpn I family (3'-ward higher frequency region) the number of copies in these genomes are as follows: human, 107,000; chimpanzee, 51,000; gorilla, 64,000; orangutan, 84,000. Thermal stability measurements show that, although the families of repeats are moderately divergent in sequence, little net sequence change has occurred during the evolution of the higher apes. Most or all of the members of these families of repeats are interspersed throughout the genome. Therefore, a large number of events of insertion and/or deletion of these DNA sequences has occurred during higher primate evolution.
|Additional Information:||Copyright © 1986 by the National Academy of Sciences Contributed by Roy J. Britten, January 27, 1986 We express appreciation to Maxine Singer for providing clones of Li repeat and to Alan Scott for the gorilla library. Primate blood samples were supplied by the Yerkes Regional Primate Center, Atlanta, GA. This work was supported by National Institutes of Health Grant GM34031. H.R.H. was supported by Kempner Fellowship from University of Texas Medical Branch at Galveston and Procter & Gamble Postdoctoral Fellowship from Caltech. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.|
|Subject Keywords:||molecular evolution; higher primates; mobile genetic elements; Alu family; Kpn I Li family|
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|Deposited By:||Archive Administrator|
|Deposited On:||06 Nov 2006|
|Last Modified:||14 Nov 2014 19:19|
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