Lewis, Susanna M. and Agard, Emily and Suh, Susie and Czyzyk, Linda (1997) Cryptic signals and the fidelity of V(D)J joining. Molecular and Cellular Biology, 17 (6). pp. 3125-3136. ISSN 0270-7306. http://resolver.caltech.edu/CaltechAUTHORS:LEWmcb97
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V(D)J recombination is responsible for the de novo creation of antigen receptor genes in T- and B-cell precursors. To the extent that lymphopoiesis takes place throughout an animal's lifetime, recombination errors present an ongoing problem. One type of aberrant rearrangement ensues when DNA sequences resembling a V(D)J joining signal are targeted by mistake. This study investigates the type of sequence likely to be subject to mistargeting, the level of joining- signal function associated with these sequences, and the number of such cryptic joining signals in the genome.
|Additional Information:||© 1997, American Society for Microbiology. Received 12 September 1996/Returned for modification 7 November 1996/Accepted 1 March 1997. We thank Joanne Hesse (NIH) for kindly providing cryptic recombinants isolated by her for sequence analysis, Greg Brown for expert technical assistance, and Veena Guru for her contributions in the construction and analysis of pCASJD. We are very grateful to J. Hesse, C. Guidos, H. Lipshitz, N. Rosenberg, M. Shulman, and G. Wu for comments on the manuscript and to M. Sadofsky for helpful discussion. This work was supported by American Cancer Society grant IM-599C and by National Cancer Institute of Canada grant no. 007362. S.L. is a Research Scientist of the National Cancer Institute of Canada.|
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|Deposited On:||08 Nov 2006|
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