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Shedding light on the dynamics of endocytosis and viral budding

Bao, Gang and Bao, X. Robert (2005) Shedding light on the dynamics of endocytosis and viral budding. Proceedings of the National Academy of Sciences of the United States of America, 102 (29). pp. 9997-9998. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:BAOpnas05

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Abstract

Endocytosis is used by eukaryotic cells to perform a wide range of functions, including the uptake of extracellular nutrients and the regulation of cell-surface receptors, as well as by toxins, viruses, and microorganisms to gain entry into cells (1). Endocytosis actually encompasses many different processes, such as phagocytosis of large (>250 nm) particles as well as pinocytosis of large volumes of fluid (2). One of the most important endocytic mechanisms is a receptor-mediated process whereby the plasma membrane binds specific macromolecules and smaller particles by means of specialized receptors, invaginates around those particles, and then pinches off to form small vesicles. Receptor-mediated endocytosis had been thought to be assisted by specific proteins, either clathrin or caveolin, polymerizing into a spherical shell around the invagination (3). Recently, however, evidence has arisen for a different, clathrin- and caveolin-independent route by which endocytosis may occur (4, 5). The understanding and quantitative analysis of the mechanisms underlying receptor-mediated endocytosis have important implications for not only viral pathogenesis but also the delivery of macromolecules and nanoparticles for intracellular imaging and targeted therapies (6).


Item Type:Article
Additional Information:© 2005 by The National Academy of Sciences of the USA. Published online before print July 11, 2005. This work was supported by National Institutes of Health Grant U01 HL080711-01 (to G.B.) and the Fannie and John Hertz Foundation (X.R.B.).
Record Number:CaltechAUTHORS:BAOpnas05
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BAOpnas05
Alternative URL:http://dx.doi.org/10.1073/pnas.0504555102
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:596
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jan 2006
Last Modified:26 Dec 2012 08:40

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