Gharib, Morteza and Rambod, Edmond and Kheradvar, Arash and Sahn, David J. and Dabiri, John O. (2006) Optimal vortex formation as an index of cardiac health. Proceedings of the National Academy of Sciences of the United States of America, 103 (16). pp. 6305-6308. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:GHApnas06
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Heart disease remains a leading cause of death worldwide. Previous research has indicated that the dynamics of the cardiac left ventricle (LV) during diastolic filling may play a critical role in dictating overall cardiac health. Hence, numerous studies have aimed to predict and evaluate global cardiac health based on quantitative parameters describing LV function. However, the inherent complexity of LV diastole, in its electrical, muscular, and hemodynamic processes, has prevented the development of tools to accurately predict and diagnose heart failure at early stages, when corrective measures are most effective. In this work, it is demonstrated that major aspects of cardiac function are reflected uniquely and sensitively in the optimization of vortex formation in the blood flow during early diastole, as measured by a dimensionless numerical index. This index of optimal vortex formation correlates well with existing measures of cardiac health such as the LV ejection fraction. However, unlike existing measures, this previously undescribed index does not require patient-specific information to determine numerical index values corresponding to normal function. A study of normal and pathological cardiac health in human subjects demonstrates the ability of this global index to distinguish disease states by a straightforward analysis of noninvasive LV measurements.
|Additional Information:||Copyright © 2006 by the National Academy of Sciences Communicated by Anatol Roshko, California Institute of Technology, Pasadena, CA, January 27, 2006 (received for review August 24, 2005) We thank the Vascular Imaging Research Center, Department of Radiology, Veterans Affairs Medical Center/University of California, San Francisco, for providing in vivo magnetic resonance images. This work was supported by the National Science Foundation. Author contributions: M.G., E.R., and D.J.S. designed research; M.G., E.R., and J.O.D. performed research; M.G., E.R., A.K., and J.O.D. contributed new reagents/analytic tools; M.G., E.R., and J.O.D. analyzed data; and M.G. and J.O.D. wrote the paper. Conflict of interest statement: No conflicts declared.|
|Subject Keywords:||cardiac dysfunction; left ventricle; mitral flow; biofluid dynamics|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||09 Nov 2006|
|Last Modified:||26 Dec 2012 09:16|
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