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Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples

Taxidis, Jiannis and Anastassiou, Costas A. and Diba, Kamran and Koch, Christof (2015) Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples. Neuron, 87 (3). pp. 590-604. ISSN 0896-6273. http://resolver.caltech.edu/CaltechAUTHORS:20151001-081003718

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Abstract

Whether the activation of spiking cell ensembles can be encoded in the local field potential (LFP) remains unclear. We address this question by combining in vivo electrophysiological recordings in the rat hippocampus with realistic biophysical modeling, and explore the LFP of place cell sequence spiking (“replays”) during sharp wave ripples. We show that multi-site perisomatic LFP amplitudes, in the ∼150–200 Hz frequency band, reliably reflect spatial constellations of spiking cells, embedded within non-spiking populations, and encode activation of local place cell ensembles during in vivo replays. We find spatiotemporal patterns in the LFP, which remain consistent between sequence replays, in conjunction with the ordered activation of place cell ensembles. Clustering such patterns provides an efficient segregation of replay events from non-replay-associated ripples. This work demonstrates how spatiotemporal ensemble spiking is encoded extracellularly, providing a window for efficient, LFP-based detection and monitoring of structured population activity in vivo.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2015.07.014DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627315006364PublisherArticle
Additional Information:© 2015 Elsevier Inc. Received: August 14, 2014; Revised: March 2, 2015; Accepted: July 20, 2015; Published: August 5, 2015. This work was funded by HFSP, the National Institute of Neurological Disorders and Stroke, the G. Harold and Leila Y. Mathers Charitable Foundation, and the UW-Milwaukee Research GroWTh Initiative. C.A.A. and C.K. wish to thank the Allen Institute founders, P. G. Allen and J. Allen, for their support. We thank Erik Schomburg for help in developing the computational model, György Buzsáki and Kenji Mizuseki for feedback on the manuscript, and Adrien Peyrache, Nathan Faivre, Adam Shai, Yazan Billeh, Michael Hill, Tristan Shuman, and Theodoros Zanos for comments on this work. Author Contributions: J.T. performed all modeling and data analyses. J.T. and C.A.A. designed analyses. K.D. conducted the experiments. J.T., C.A.A., K.D., and C.K. designed the research and wrote the manuscript.
Group:KLAB, Koch Laboratory
Funders:
Funding AgencyGrant Number
Human Frontier Science Program (HFSP)UNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
G. Harold and Leila Y. Mathers Charitable FoundationUNSPECIFIED
University of Wisconsin-Milwaukee Research GroWTh InitiativeUNSPECIFIED
Record Number:CaltechAUTHORS:20151001-081003718
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20151001-081003718
Official Citation:Jiannis Taxidis, Costas A. Anastassiou, Kamran Diba, Christof Koch, Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples, Neuron, Volume 87, Issue 3, 5 August 2015, Pages 590-604, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2015.07.014. (http://www.sciencedirect.com/science/article/pii/S0896627315006364)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:60645
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Oct 2015 17:30
Last Modified:02 Oct 2015 16:43

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