Taxidis, Jiannis and Anastassiou, Costas A. and Diba, Kamran and Koch, Christof (2015) Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples. Neuron, 87 (3). pp. 590-604. ISSN 0896-6273. http://resolver.caltech.edu/CaltechAUTHORS:20151001-081003718
PDF (Supplemental Experimental Procedures and Figures S1-S7)
- Supplemental Material
See Usage Policy.
Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20151001-081003718
Whether the activation of spiking cell ensembles can be encoded in the local field potential (LFP) remains unclear. We address this question by combining in vivo electrophysiological recordings in the rat hippocampus with realistic biophysical modeling, and explore the LFP of place cell sequence spiking (“replays”) during sharp wave ripples. We show that multi-site perisomatic LFP amplitudes, in the ∼150–200 Hz frequency band, reliably reflect spatial constellations of spiking cells, embedded within non-spiking populations, and encode activation of local place cell ensembles during in vivo replays. We find spatiotemporal patterns in the LFP, which remain consistent between sequence replays, in conjunction with the ordered activation of place cell ensembles. Clustering such patterns provides an efficient segregation of replay events from non-replay-associated ripples. This work demonstrates how spatiotemporal ensemble spiking is encoded extracellularly, providing a window for efficient, LFP-based detection and monitoring of structured population activity in vivo.
|Additional Information:||© 2015 Elsevier Inc. Received: August 14, 2014; Revised: March 2, 2015; Accepted: July 20, 2015; Published: August 5, 2015. This work was funded by HFSP, the National Institute of Neurological Disorders and Stroke, the G. Harold and Leila Y. Mathers Charitable Foundation, and the UW-Milwaukee Research GroWTh Initiative. C.A.A. and C.K. wish to thank the Allen Institute founders, P. G. Allen and J. Allen, for their support. We thank Erik Schomburg for help in developing the computational model, György Buzsáki and Kenji Mizuseki for feedback on the manuscript, and Adrien Peyrache, Nathan Faivre, Adam Shai, Yazan Billeh, Michael Hill, Tristan Shuman, and Theodoros Zanos for comments on this work. Author Contributions: J.T. performed all modeling and data analyses. J.T. and C.A.A. designed analyses. K.D. conducted the experiments. J.T., C.A.A., K.D., and C.K. designed the research and wrote the manuscript.|
|Group:||KLAB, Koch Laboratory|
|Official Citation:||Jiannis Taxidis, Costas A. Anastassiou, Kamran Diba, Christof Koch, Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples, Neuron, Volume 87, Issue 3, 5 August 2015, Pages 590-604, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2015.07.014. (http://www.sciencedirect.com/science/article/pii/S0896627315006364)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||01 Oct 2015 17:30|
|Last Modified:||02 Oct 2015 16:43|
Repository Staff Only: item control page