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Molecular evolution of the vertebrate immune system

Bartl, Simona and Baltimore, David and Weissman, Irving L. (1994) Molecular evolution of the vertebrate immune system. Proceedings of the National Academy of Sciences of the United States of America, 91 (23). pp. 10769-10770. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:BARpnas94

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Abstract

An understanding of the evolution of vertebrate immunity is slowly emerging from studies of chordates that share distant ancestors with mammals. In higher vertebrates, such as birds and mammals, we know that two receptor systems are operative. B cells use immunoglobulins to bind foreign agents (the functionally defined antigens). T cells use T-cell receptors (TCRs) to respond to antigen in the form of processed peptides bound to cell surface proteins encoded in the major histocompatibility complex (MHC). Thus, for T cells, two receptor molecules are required for recognition of antigen. First, the MHC molecule on the infected cell binds the processed antigenic peptide; second, the TCR binds the MHC molecule-antigenic peptide complex.


Item Type:Article
Additional Information:Copyright © 1994 by The National Academy of Sciences.
Record Number:CaltechAUTHORS:BARpnas94
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BARpnas94
Alternative URL:http://www.pnas.org/cgi/reprint/91/23/10769
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:607
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:01 Sep 2005
Last Modified:26 Dec 2012 08:40

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