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α-Aminoadipic acid as a precursor to lysine in Neurospora

Windsor, Emanuel (1951) α-Aminoadipic acid as a precursor to lysine in Neurospora. Journal of Biological Chemistry, 192 (2). pp. 607-609. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:WINjbc51a

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Abstract

In a recent investigation reported by Mitchell and Houlahan (1) it was shown that a mutant strain of Neurospora crassa, strain 33933, was able to utilize α-aminoadipic acid in place of lysine. Although these authors interpreted their results as showing that oc-aminoadipic acid was a precursor in the biosynthesis of lysine by Neurospora, other pathways are conceivable. During the isolation of α-aminoadipic acid from a natural protein radioactive α-aminoadipic acid was added as a marker for chromatographic analysis (2). In order to identify the isolated amino acid an aliquot was provided as a growth substance for the Neurospora mutant 33933. Thus the opportunity was available to follow the radioactivity and determine whether or not α-aminoadipic acid was a precursor to lysine.


Item Type:Article
Additional Information:Copyright © 1951 by the American Society for Biochemistry and Molecular Biology. (Received for publication, May 22, 1951) Part of this work was taken from a thesis in partial fulfilment of the requirements for the degree of Doctor of Philosophy.
Record Number:CaltechAUTHORS:WINjbc51a
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:WINjbc51a
Alternative URL:http://www.jbc.org/content/vol192/issue2/index.shtml
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6204
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:28 Nov 2006
Last Modified:26 Dec 2012 09:18

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