El-Samad, H. and Kurata, H. and Doyle, J. C. and Gross, C. A. and Khammash, M. (2005) Surviving heat shock: Control strategies for robustness and performance. Proceedings of the National Academy of Sciences of the United States of America, 102 (8). pp. 2736-2741. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:ELSpnas05
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Molecular biology studies the cause-and-effect relationships among microscopic processes initiated by individual molecules within a cell and observes their macroscopic phenotypic effects on cells and organisms. These studies provide a wealth of information about the underlying networks and pathways responsible for the basic functionality and robustness of biological systems. At the same time, these studies create exciting opportunities for the development of quantitative and predictive models that connect the mechanism to its phenotype then examine various modular structures and the range of their dynamical behavior. The use of such models enables a deeper understanding of the design principles underlying biological organization and makes their reverse engineering and manipulation both possible and tractable The heat shock response presents an interesting mechanism where such an endeavor is possible. Using a model of heat shock, we extract the design motifs in the system and justify their existence in terms of various performance objectives. We also offer a modular decomposition that parallels that of traditional engineering control architectures.
|Additional Information:||© 2005 by The National Academy of Sciences. This paper was submitted directly (Track II) to the PNAS office. Edited by Melvin I. Simon, California Institute of Technology, Pasadena, CA, and approved December 16, 2004 (received for review May 18, 2004). Published online before print January 24, 2005, 10.1073/pnas.0403510102 We thank Irina Grigorova for critical reading of the manuscript. This work was supported by National Science Foundation Grant CCF-0326576 and Institute for Collaborative Biotechnologies Grant DAAD19-03-D-0004 from the U.S. Army Research Office.|
|Subject Keywords:||control theory, heat shock stress response, mathematical modeling|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||08 Sep 2005|
|Last Modified:||26 Dec 2012 08:40|
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