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Sequence of mRNA Coding for Bindin, a Species-Specific Sea Urchin Sperm Protein Required for Fertilization

Gao, Boning and Klein, Laurie E. and Britten, Roy J. and Davidson, Eric H. (1986) Sequence of mRNA Coding for Bindin, a Species-Specific Sea Urchin Sperm Protein Required for Fertilization. Proceedings of the National Academy of Sciences of the United States of America, 83 (22). pp. 8634-8638. ISSN 0027-8424. PMCID PMC386985. http://resolver.caltech.edu/CaltechAUTHORS:GAOpnas86

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Abstract

Bindin, a major protein of the sea urchin acrosome granule, mediates the species-specific adhesion and binding of sperm to egg required to effect fertilization. We report the isolation and sequence of bindin cDNA clones prepared from Strongylocentrotus purpuratus testis RNA. The bindin gene appears to be productively expressed only in males and only in testes. The protein is produced from a 51-kDa precursor, which is subsequently processed to yield the mature 24-kDa bindin protein.


Item Type:Article
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC386985/PubMed CentralArticle
Additional Information:Copyright © 1986 by the National Academy of Sciences Contributed by Eric H. Davidson, July 24, 1986 We thank Dr. V. Vacquier for the generous gift of bindin protein and bindin antibody. We also thank Dr. S. J. Horvath for providing synthetic probes and primer, and Mr. J. A. Ferrier for technical assistance. B.G. was supported in part by the California Foundation for Biomedical Research. This research was supported by Grant DCB8502191 from the National Science Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
California Foundation for Biomedical ResearchUNSPECIFIED
NSFDCB8502191
PubMed Central ID:PMC386985
Record Number:CaltechAUTHORS:GAOpnas86
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:GAOpnas86
Alternative URL:http://www.pnas.org/cgi/content/abstract/83/22/8634
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6642
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:16 Dec 2006
Last Modified:18 Dec 2015 02:38

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