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A Novel Closed-Circular Mitochondrial DNA with Properties of a Replicating Intermediate

Kasamatsu, Harumi and Robberson, Donald L. and Vinograd, Jerome (1971) A Novel Closed-Circular Mitochondrial DNA with Properties of a Replicating Intermediate. Proceedings of the National Academy of Sciences of the United States of America, 68 (9). pp. 2252-2257. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:KASpnas71

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Abstract

A fraction of the covalently closed mitochondrial DNA in mouse L cells contains a replicated heavy-strand segment that is hydrogen bonded to the circular light strand. The inserted single strand is dissociable from the circular duplex at an elevated temperature.


Item Type:Article
Additional Information:Copyright © 1971 by the National Academy of Sciences Contributed by Jerome Vinograd, June 18, 1971 We gratefully acknowledge the valued assistance of M. Teplitz and J. Edens and the gifts of SV40[22P] DNA and T7[14C]DNA from C.J.B. Tibbetts and L.I. Grossman, respectively. This investigation was supported by USPHS grants CA08014 from the National Cancer Institute and GM15327, GM00086, and GM10991 from the National Institute of General Medical Sciences. H.K. is the recipient of a postdoctoral fellowship from the Helen Hay Whitney Foundation. This is contribution no. 4264 from the Division of Chemistry and Chemical Engineering.
Record Number:CaltechAUTHORS:KASpnas71
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:KASpnas71
Alternative URL:http://www.pnas.org/cgi/content/abstract/68/9/2252
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6732
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:19 Dec 2006
Last Modified:26 Dec 2012 09:24

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