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Myeloma Proteins from NZB and BALB/c Mice: Structural and Functional Differences

Loh, E. and Black, B. and Riblet, R. and Weigert, M. and Hood, J. M. and Hood, L. (1979) Myeloma Proteins from NZB and BALB/c Mice: Structural and Functional Differences. Proceedings of the National Academy of Sciences of the United States of America, 76 (3). pp. 1395-1399. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:LOHpnas79

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Abstract

Structural and functional analyses of myeloma immunoglobulins from inbred BALB/c mice and humans have provided important insights into the structure of the antibody molecule and the expression and evolution of antibody genes. One important question concerning these analyses is whether the myeloma process selects, in a nonrandom manner, the lymphocytes to be transformed. The availability of myeloma tumors in a second inbred strain of mouse, NZB, permits us to approach this question. In this respect, the NH2-terminal amino acid sequences of 27 kappa light chains as well as data relating to the antigen-binding properties and immunoglobulin class distribution of NZB myeloma proteins are presented and compared with similar data from the BALB/c mouse. These studies suggest that the myeloma proteins from the BALB/c and NZB mice constitute two populations of immunoglobulins with distinct functional and structural properties. The implications of this observation are discussed.


Item Type:Article
Additional Information:Copyright © 1979 by the National Academy of Sciences Communicated by Ray D. Owen, September 25, 1978 This work was supported by grants from the National Institutes of Health. E.L. was supported by a National Institutes of Health Graduate Research Training Grant. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.
Subject Keywords:protein sequence; genealogical analysis; NZB myeloma immunoglobulins
Record Number:CaltechAUTHORS:LOHpnas79
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:LOHpnas79
Alternative URL:http://www.pnas.org/cgi/content/abstract/76/3/1395
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6758
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:20 Dec 2006
Last Modified:26 Dec 2012 09:24

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